Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 12/20 | 0.46 |
| ▸ | LTA4H | P09960 | 5/20 | 0.45 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5743847 | 0.81 | ACE (0.55) | ACELTA4HACE2TSHR | |
| SCHEMBL2853081 | 0.74 | CHRM1 (0.41) | ALDH1A1TSHR | |
| Hydrochloric Acid SCHEMBL6681607 | 0.72 | MCHR1 (0.44) | LTA4HALDH1A1TSHR | |
| SCHEMBL4528488 | 0.71 | L3MBTL1 (0.49) | SMN1; SMN2TSHR | |
| SCHEMBL4395886 | 0.71 | HPGD (0.47) | ALDH1A1TSHR | |
| SCHEMBL5656404 | 0.70 | NPC1 (0.43) | LTA4HSMN1; SMN2TSHR | |
| SCHEMBL6100005 | 0.70 | ALDH1A1 (0.48) | ALDH1A1TSHR | |
| SCHEMBL3708454 | 0.70 | CYP1A2 (0.40) | ALDH1A1TSHR | |
| SCHEMBL9554734 | 0.70 | ACE (0.81) | ACELTA4HACE2 | |
| SCHEMBL9554742 | 0.70 | ACE (0.81) | ACELTA4HACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7825256-B2 | Inducible nitric oxide synthase dimerization inhibitors | KALYPSYS, INC. (US) | 2010-11-02 | — | — | US | disclosed |
| EP-1817030-A2 | INDUCIBLE NITRIC OXIDE SYNTHASE DIMERIZATION INHIBITORS | Kalypsys, Inc. (US) | 2007-08-15 | — | — | EP | disclosed |
| WO-2006060424-A2 | INDUCIBLE NITRIC OXIDE SYNTHASE DIMERIZATION INHIBITORS | KALYPSYS, INC. (US) | 2006-06-08 | — | — | WO | disclosed |
| US-20060116515-A1 | Inducible nitric oxide synthase dimerization inhibitors | KALYPSYS, INC. | 2006-06-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060116515-A1 | Inducible nitric oxide synthase dimerization inhibitors | NOS3, NOS2, NOS1 | ACE 4268/4885LTA4H 1457/4885ACE2 4098/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.