Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 4/20 | 0.59 |
| ▸ | AKR1C3 | P42330 | 6/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.44 |
| ▸ | NQO2 | P16083 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | EP300 | Q09472 | 2/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28693273 | 0.88 | MTNR1A (0.49) | MTNR1AAKR1C3AKR1C2ALDH1A1HPGD | |
| SCHEMBL27998896 | 0.83 | MTNR1A (0.57) | MTNR1AAKR1C3AKR1C2ALDH1A1HPGD | |
| SCHEMBL13121580 | 0.81 | BAZ2B (0.56) | MTNR1AALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL13172044 | 0.81 | MTNR1A (0.55) | MTNR1AAKR1C3AKR1C2ALDH1A1HPGD | |
| SCHEMBL2887696 | 0.81 | MTNR1A (0.55) | MTNR1AAKR1C3AKR1C2ALDH1A1 | |
| SCHEMBL30394848 | 0.81 | MTNR1A (0.55) | MTNR1AAKR1C3AKR1C2ALDH1A1HPGD | |
| SCHEMBL28684424 | 0.79 | RAB9A (0.42) | MTNR1AALDH1A1MAPTSMN1; SMN2RAB9A | |
| SCHEMBL22919631 | 0.78 | MAOB (0.56) | RAB9ANPC1BAZ2B | |
| SCHEMBL3567471 | 0.78 | ALDH1A1 (0.41) | MTNR1AAKR1C3AKR1C2ALDH1A1HPGD | |
| SCHEMBL1271943 | 0.78 | PDGFRA (0.41) | MTNR1AHPGDMAPTSMN1; SMN2CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114057625-B | C2-acyloxy-3-indolinone derivative and preparation method and application thereof | 五邑大学 | 2023-11-24 | — | — | CN | disclosed |
| CN-114057625-A | C2-acyloxy-3-indolinone derivative and preparation method and application thereof | 五邑大学 | 2022-02-18 | — | — | CN | disclosed |
| EP-1567492-B1 | N-ARYLSULFONYL-3-AMINOALKOXYINDOLES | SUVEN LIFE SCIENCES LTD (IN) | 2013-05-22 | — | — | EP | disclosed |
| EP-1751156-B1 | 6,7,8,9-SUBSTITUTED 1-PHENYL-1,5-DIHYDRO-PYRIDO(3,2-B)INDOL-2-ONES USEFUL AS ANTI-INFECTIVE PHARMACEUTICAL AGENTS | TIBOTEC PHARM LTD (IE) | 2010-09-15 | — | — | EP | disclosed |
| US-7718690-B2 | N-arylsulfonyl-3-aminoalkoxyindoles | RAMAKRISHNA VENKATA SATYA NIROGI | 2010-05-18 | — | — | US | disclosed |
| US-20100029635-A1 | 6,7,8,9-SUBSTITUTED 1-PHENYL-1,5-DIHYDRO-PYRIDO[3,2-B]INDOL-2-ONES USEFUL AS ANTI-INFECTIVE PHARMACEUTICAL AGENTS | KESTELEYN BART RUDOLF ROMANIE | 2010-02-04 | — | — | US | disclosed |
| US-20100029635-A1 | 6,7,8,9-SUBSTITUTED 1-PHENYL-1,5-DIHYDRO-PYRIDO[3,2-B]INDOL-2-ONES USEFUL AS ANTI-INFECTIVE PHARMACEUTICAL AGENTS | KESTELEYN BART RUDOLF ROMANIE | 2010-02-04 | — | — | US | disclosed |
| US-7622581-B2 | 6,7,8,9-substituted 1-phenyl-1,5-dihydro-pyrido[3,2-b]indol-2-ones useful as anti-infective pharmaceutical agents | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2009-11-24 | — | — | US | disclosed |
| US-7622581-B2 | 6,7,8,9-substituted 1-phenyl-1,5-dihydro-pyrido[3,2-b]indol-2-ones useful as anti-infective pharmaceutical agents | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2009-11-24 | — | — | US | disclosed |
| US-20090131507-A1 | N-arylsulfonyl-3-aminoalkoxyindoles | SUVEN LIFE SCIENCES LIMITED (IN) | 2009-05-21 | — | — | US | disclosed |
| US-7531568-B2 | PPAR active compounds | PLEXXIKON, INC. (US) | 2009-05-12 | — | — | US | disclosed |
| US-7531568-B2 | PPAR active compounds | PLEXXIKON, INC. (US) | 2009-05-12 | — | — | US | disclosed |
| EP-1819673-A2 | INDOLE DERIVATIVES FOR USE AS PPAR ACTIVE COMPOUNDS | PLEXXIKON, INC. (US) | 2007-08-22 | — | — | EP | disclosed |
| US-20070167434-A1 | 6,7,8,9-Substituted 1-phenyl-1,5-dihydro-pyrido[3,2-b]indol-2-ones useful as anti-infective pharmaceutical agents | TIBOTEC BVBA (BE) | 2007-07-19 | — | — | US | disclosed |
| US-20070167434-A1 | 6,7,8,9-Substituted 1-phenyl-1,5-dihydro-pyrido[3,2-b]indol-2-ones useful as anti-infective pharmaceutical agents | TIBOTEC BVBA (BE) | 2007-07-19 | — | — | US | disclosed |
| WO-2006060456-A2 | INDOLE DERIVATIVES FOR USE AS PPAR PPAR ACTIVE COMPOUNDS | PLEXXIKON, INC. (US) | 2006-06-08 | — | — | WO | disclosed |
| US-20060116416-A1 | PPAR active compounds | PLEXXIKON, INC | 2006-06-01 | — | — | US | disclosed |
| EP-1567492-A2 | N-ARYLSULFONYL-3-AMINOALKOXYINDOLES | Suven Life Sciences Limited (IN) | 2005-08-31 | — | — | EP | disclosed |
| WO-2004048328-A2 | N-ARYLSULFONYL-3-AMINOALKOXYINDOLES | SUVEN LIFE SCIENCES LIMITED (IN) | 2004-06-10 | — | — | WO | disclosed |
| WO-2004048331-A1 | N-ARYLALKYL-3-AMINOALKOXYINDOLES AND THEIR USE AS 5-HT LIGANDS | SUVEN LIFE SCIENCES LIMITED (IN) | 2004-06-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131507-A1 | N-arylsulfonyl-3-aminoalkoxyindoles | HTR3C, HTR3A, AANAT | MTNR1A 143/4885AKR1C3 1540/4885AKR1C2 1900/4885 |
| US-20100029635-A1 | 6,7,8,9-SUBSTITUTED 1-PHENYL-1,5-DIHYDRO-PYRIDO[3,2-B]INDOL-2-ONES USEFUL AS ANTI-INFECTIVE PHARMACEUTICAL AGENTS | HRH4, CBR1, HRH2 | MTNR1A 70/4885AKR1C3 439/4885AKR1C2 986/4885 |
| US-20070167434-A1 | 6,7,8,9-Substituted 1-phenyl-1,5-dihydro-pyrido[3,2-b]indol-2-ones useful as anti-infective pharmaceutical agents | HRH4, CBR1, HRH2 | MTNR1A 62/4885AKR1C3 370/4885AKR1C2 909/4885 |
| US-20060116416-A1 | PPAR active compounds | PPARG, PPARA, PPARD | MTNR1A 191/4885AKR1C3 3078/4885AKR1C2 2253/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.