Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | NQO2 | P16083 | 2/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28488115 | 0.92 | KDM4E (0.42) | ALDH1A1KDM4EGAAGLAATM | |
| SCHEMBL21558450 | 0.88 | ATM (0.44) | ALDH1A1KDM4EGAAGLAATM | |
| SCHEMBL4255028 | 0.88 | LMNA (0.44) | ALDH1A1KDM4EGAAGLAATM | |
| SCHEMBL31347599 | 0.87 | KDM4E (0.41) | ALDH1A1KDM4EGAAGLAATM | |
| SCHEMBL6507153 | 0.87 | KDM4E (0.41) | ALDH1A1KDM4EGAAGLAATM | |
| SCHEMBL15240033 | 0.87 | L3MBTL1 (0.42) | ALDH1A1KDM4EGAAGLAATM | |
| SCHEMBL29741070 | 0.82 | GAA (0.46) | ALDH1A1KDM4EGAAGLAATM | |
| SCHEMBL29741272 | 0.82 | TSHR (0.39) | ALDH1A1KDM4EGAAGLAATM | |
| SCHEMBL14893447 | 0.80 | ATM (0.49) | ALDH1A1KDM4EGAAGLAATM | |
| SCHEMBL10467534 | 0.80 | ALDH1A1 (0.48) | ALDH1A1KDM4EGAAGLAATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105793254-B | Azaquinazoline carboxamide derivatives | 默克专利有限公司 | 2020-10-23 | — | — | CN | disclosed |
| US-10233160-B2 | Substituted pyrido[3,4-d]pyrimidines and pyrido[4,3-d]pyrimidines as p70S6K inhibitors | MERCK PATENT GMBH (DE) | 2019-03-19 | — | — | US | disclosed |
| US-10233160-B2 | Substituted pyrido[3,4-d]pyrimidines and pyrido[4,3-d]pyrimidines as p70S6K inhibitors | MERCK PATENT GMBH (DE) | 2019-03-19 | — | — | US | disclosed |
| US-20180237402-A1 | AZAQUINAZOLINE CARBOXAMIDE DERIVATIVES | MERCK PATENT GMBH (DE) | 2018-08-23 | — | — | US | disclosed |
| US-9981925-B2 | Substituted benzo[d][1,2,3]triazines as p70S6K inhibitors | MERCK PATENT GMBH (DE) | 2018-05-29 | — | — | US | disclosed |
| US-9981925-B2 | Substituted benzo[d][1,2,3]triazines as p70S6K inhibitors | MERCK PATENT GMBH (DE) | 2018-05-29 | — | — | US | disclosed |
| US-9981925-B2 | Substituted benzo[d][1,2,3]triazines as p70S6K inhibitors | MERCK PATENT GMBH (DE) | 2018-05-29 | — | — | US | disclosed |
| US-20160340323-A1 | AZAQUINAZOLINE CARBOXAMIDE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-11-24 | — | — | US | disclosed |
| US-20160340323-A1 | AZAQUINAZOLINE CARBOXAMIDE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-11-24 | — | — | US | disclosed |
| US-20160340323-A1 | AZAQUINAZOLINE CARBOXAMIDE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-11-24 | — | — | US | disclosed |
| WO-2014085528-A1 | AZAQUINAZOLINE CARBOXAMIDE DERIVATIVES | MERCK PATENT GMBH (DE) | 2014-06-05 | — | — | WO | disclosed |
| WO-2014085528-A1 | AZAQUINAZOLINE CARBOXAMIDE DERIVATIVES | MERCK PATENT GMBH (DE) | 2014-06-05 | — | — | WO | disclosed |
| US-7659307-B2 | Nonphytotoxic; 4-Bromo-3-methoxy-N-4-[4(trifluoromethyl)phenoxy]phenyl-thiophene-2-carboxamide; 4-[(Allyloxycarbonyl)amino]-3-methoxy-N-4-[4-(trifluoromethyl)phenoxy]phenyl-thiophene-2-carboxamide | BAYER CROPSCIENCE S.A. (FR) | 2010-02-09 | — | — | US | disclosed |
| US-7659307-B2 | Nonphytotoxic; 4-Bromo-3-methoxy-N-4-[4(trifluoromethyl)phenoxy]phenyl-thiophene-2-carboxamide; 4-[(Allyloxycarbonyl)amino]-3-methoxy-N-4-[4-(trifluoromethyl)phenoxy]phenyl-thiophene-2-carboxamide | BAYER CROPSCIENCE S.A. (FR) | 2010-02-09 | — | — | US | disclosed |
| US-7659307-B2 | Nonphytotoxic; 4-Bromo-3-methoxy-N-4-[4(trifluoromethyl)phenoxy]phenyl-thiophene-2-carboxamide; 4-[(Allyloxycarbonyl)amino]-3-methoxy-N-4-[4-(trifluoromethyl)phenoxy]phenyl-thiophene-2-carboxamide | BAYER CROPSCIENCE S.A. (FR) | 2010-02-09 | — | — | US | disclosed |
| US-20060205732-A1 | Heterocyclic carboxamides and their use as fungicides | BAYER SAS (FR) | 2006-09-14 | — | — | US | disclosed |
| US-7084163-B2 | Heterocyclic carboxamides and their use as fungicides | BAYER CROPSCIENCE S.A. (FR) | 2006-08-01 | — | — | US | disclosed |
| US-20040152698-A1 | Heterocyclic carboxamides and their use as fungicides | BAYER SAS (FR) | 2004-08-05 | — | — | US | disclosed |
| EP-1425276-A2 | HETEROCYCLIC CARBOXAMIDES AND THEIR USE AS FUNGICIDES | Bayer CropScience S.A. (FR) | 2004-06-09 | — | — | EP | disclosed |
| WO-2003006454-A2 | HETEROCYCLIC CARBOXAMIDES AND THEIR USE AS FUNGICIDES | BAYER CROPSCIENCE S.A. (FR) | 2003-01-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040152698-A1 | Heterocyclic carboxamides and their use as fungicides | CYP1A2, CYP4X1, CYCS | ALDH1A1 3137/4885KDM4E 543/4885GAA 319/4885 |
| US-20180237402-A1 | AZAQUINAZOLINE CARBOXAMIDE DERIVATIVES | RPS6KA3, RPS6KA4, CDK4 | ALDH1A1 3527/4885KDM4E 550/4885GAA 3572/4885 |
| US-20060205732-A1 | Heterocyclic carboxamides and their use as fungicides | CYP4X1, CYP1A2, CYCS | ALDH1A1 2827/4885KDM4E 501/4885GAA 553/4885 |
| US-20160340323-A1 | AZAQUINAZOLINE CARBOXAMIDE DERIVATIVES | RPS6KA3, RPS6KA4, CDK4 | ALDH1A1 3527/4885KDM4E 550/4885GAA 3572/4885 |
| US-10233160-B2 | Substituted pyrido[3,4-d]pyrimidines and pyrido[4,3-d]pyrimidines as p70S6K inhibitors | CDK4, CDK2, RPS6KA4 | ALDH1A1 3625/4885KDM4E 623/4885GAA 3924/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.