Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 6/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MC4R | P32245 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.38 |
| ▸ | AHR | P35869 | 2/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14870330 | 0.92 | CYP2A6 (0.44) | SIRT2SIRT1MAPTKDM4EMEN1 | |
| SCHEMBL3568497 | 0.89 | MAPT (0.52) | SIRT2SIRT1MAOBLMNAMAPT | |
| SCHEMBL18735948 | 0.87 | MEN1 (0.42) | MAOBLMNAMAPTHTTBLM | |
| SCHEMBL29587448 | 0.87 | MEN1 (0.42) | MAOBLMNAMAPTHTTBLM | |
| SCHEMBL3565631 | 0.86 | MAPT (0.44) | SIRT2SIRT1MAOBLMNAMAPT | |
| SCHEMBL3568948 | 0.86 | MAPT (0.44) | SIRT2SIRT1LMNAMAPTHTT | |
| SCHEMBL13568115 | 0.80 | LMNA (0.44) | SIRT2SIRT1MAOBLMNAMAPT | |
| SCHEMBL13568204 | 0.78 | MAPT (0.38) | SIRT2SIRT1LMNAMAPTHTT | |
| SCHEMBL14548104 | 0.78 | MAPT (0.38) | SIRT2SIRT1LMNAMAPTHTT | |
| SCHEMBL24399507 | 0.77 | LMNA (0.41) | SIRT2SIRT1LMNAMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7771801-B2 | Chiral compounds | MERCK PATENT GMBH (DE) | 2010-08-10 | — | — | US | disclosed |
| US-7771801-B2 | Chiral compounds | MERCK PATENT GMBH (DE) | 2010-08-10 | — | — | US | disclosed |
| EP-1928854-B1 | CHIRAL COMPOUNDS | MERCK PATENT GMBH (DE) | 2009-12-16 | — | — | EP | disclosed |
| US-20080281108-A1 | Chiral Compounds | MERCK PATENT GMBH (DE) | 2008-11-13 | — | — | US | disclosed |
| US-20080281108-A1 | Chiral Compounds | MERCK PATENT GMBH (DE) | 2008-11-13 | — | — | US | disclosed |
| WO-2007124383-A2 | 1,1'-BINAPHTHYL-BASED INHIBITORS OF NAD+-DEPENDENT DEACETYLASE ACTIVITY AND SIR2-FAMILY MEMBERS | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2007-11-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080281108-A1 | Chiral Compounds | LAGE3, DDT, CUTA | SIRT2 1231/4885SIRT1 993/4885MAOB 998/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.