Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.67 |
| ▸ | HPGD | P15428 | 2/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | BLM | P54132 | 1/20 | 0.67 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 2/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | CTSG | P08311 | 1/20 | 0.38 |
| ▸ | CMA1 | P23946 | 1/20 | 0.38 |
| ▸ | CTRC | Q99895 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL356681 | 0.90 | ALDH1A1 (0.80) | ALDH1A1HPGDHSD17B10KDM4ECYP1A2 | |
| SCHEMBL3970272 | 0.88 | ALDH1A1 (0.77) | ALDH1A1HPGDHSD17B10KDM4ECYP1A2 | |
| Pirfenidone SCHEMBL27872362 | 0.87 | ALDH1A1 (0.83) | ALDH1A1HPGDHSD17B10KDM4ECYP1A2 | |
| SCHEMBL3300511 | 0.83 | ALDH1A1 (0.59) | ALDH1A1HPGDHSD17B10KDM4ECYP1A2 | |
| SCHEMBL3302369 | 0.81 | ALDH1A1 (0.67) | ALDH1A1HPGDHSD17B10KDM4ECYP1A2 | |
| SCHEMBL3975362 | 0.81 | ALDH1A1 (0.67) | ALDH1A1HPGDHSD17B10KDM4ECYP1A2 | |
| SCHEMBL147877 | 0.81 | ALDH1A1 (0.67) | ALDH1A1HPGDHSD17B10KDM4ECYP1A2 | |
| Hydronidone SCHEMBL143564 | 0.81 | ALDH1A1 (0.67) | ALDH1A1HPGDHSD17B10KDM4ECYP1A2 | |
| SCHEMBL9892413 | 0.81 | ALDH1A1 (0.67) | ALDH1A1HPGDHSD17B10KDM4ECYP1A2 | |
| SCHEMBL3306525 | 0.80 | ALDH1A1 (0.56) | ALDH1A1HPGDHSD17B10KDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010045871-A1 | COMPOSITION AND METHOD FOR TREATING PROTEINURIA | DIERETECH INVESTMENT LIMITED (CN) | 2010-04-29 | — | — | WO | claimed |
| US-20100099719-A1 | COMPOSITION AND METHOD FOR TREATING PROTEINURIA | DIEREPHARMA, INC. (US) | 2010-04-22 | — | — | US | claimed |
| US-20090258911-A1 | COMPOSITION AND METHOD FOR TREATING FIBROTIC DISEASES | TAO LI JIAN | 2009-10-15 | — | — | US | claimed |
| US-20090005424-A9 | Composition and Method for Treating Fibrotic Diseases | TAO LI J | 2009-01-01 | — | — | US | claimed |
| EP-1878428-A1 | 1-(SUBSTITUTED PHENYL)-5- METHYL- 2 - (1H) PYRIDONE IN THE MANUFACTURE OF MEDICAMENTS FOR TREATING FIBROSIS IN ORGANS OR TISSUES | Xiangya Hospital of Central South University (CN) | 2008-01-16 | — | — | EP | claimed |
| US-20070203203-A1 | Composition and Method for Treating Fibrotic Diseases | TAO LI J | 2007-08-30 | — | — | US | claimed |
| WO-2010045871-A1 | COMPOSITION AND METHOD FOR TREATING PROTEINURIA | DIERETECH INVESTMENT LIMITED (CN) | 2010-04-29 | — | — | WO | disclosed |
| US-20100099719-A1 | COMPOSITION AND METHOD FOR TREATING PROTEINURIA | DIEREPHARMA, INC. (US) | 2010-04-22 | — | — | US | disclosed |
| US-20090258911-A1 | COMPOSITION AND METHOD FOR TREATING FIBROTIC DISEASES | TAO LI JIAN | 2009-10-15 | — | — | US | disclosed |
| US-20090005424-A9 | Composition and Method for Treating Fibrotic Diseases | TAO LI J | 2009-01-01 | — | — | US | disclosed |
| US-20080319027-A1 | Composition and Method for Treating Fibrotic Diseases | TAO LI JIAN | 2008-12-25 | — | — | US | disclosed |
| EP-1878428-A1 | 1-(SUBSTITUTED PHENYL)-5- METHYL- 2 - (1H) PYRIDONE IN THE MANUFACTURE OF MEDICAMENTS FOR TREATING FIBROSIS IN ORGANS OR TISSUES | Xiangya Hospital of Central South University (CN) | 2008-01-16 | — | — | EP | disclosed |
| US-20070203203-A1 | Composition and Method for Treating Fibrotic Diseases | TAO LI J | 2007-08-30 | — | — | US | disclosed |
| US-20050158240-A1 | Method for labeling with tritium | NAGASAKI TOHRU (JP) | 2005-07-21 | — | — | US | disclosed |
| US-20030194748-A1 | Method for labeling with tritium | SHIONOGI & CO., LTD. (JP) | 2003-10-16 | — | — | US | disclosed |
| EP-1285902-A1 | METHOD FOR LABELING WITH TRITIUM | SHIONOGI & CO., LTD. (JP) | 2003-02-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030194748-A1 | Method for labeling with tritium | DUT, TK1, SSTR5 | ALDH1A1 2402/4885HPGD 2547/4885HSD17B10 2730/4885 |
| US-20100099719-A1 | COMPOSITION AND METHOD FOR TREATING PROTEINURIA | REN, PTPRF, PPM1F | ALDH1A1 341/4885HPGD 666/4885HSD17B10 632/4885 |
| US-20090005424-A9 | Composition and Method for Treating Fibrotic Diseases | COL1A1, COL2A1, MMP1 | ALDH1A1 485/4885HPGD 366/4885HSD17B10 685/4885 |
| US-20080319027-A1 | Composition and Method for Treating Fibrotic Diseases | COL1A1, COL2A1, MMP1 | ALDH1A1 485/4885HPGD 366/4885HSD17B10 685/4885 |
| US-20050158240-A1 | Method for labeling with tritium | DUT, TK1, SSTR5 | ALDH1A1 2402/4885HPGD 2547/4885HSD17B10 2730/4885 |
| US-20090258911-A1 | COMPOSITION AND METHOD FOR TREATING FIBROTIC DISEASES | COL1A1, COL2A1, MMP1 | ALDH1A1 485/4885HPGD 366/4885HSD17B10 685/4885 |
| US-20070203203-A1 | Composition and Method for Treating Fibrotic Diseases | COL1A1, COL2A1, MMP1 | ALDH1A1 485/4885HPGD 366/4885HSD17B10 685/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.