Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.67 |
| ▸ | BLM | P54132 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | COMT | P21964 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL356681 | 0.90 | ALDH1A1 (0.80) | ALDH1A1KDM4ECYP1A2HPGDBLM | |
| SCHEMBL3970272 | 0.88 | ALDH1A1 (0.77) | ALDH1A1KDM4ECYP1A2HPGDBLM | |
| SCHEMBL147877 | 0.81 | ALDH1A1 (0.67) | ALDH1A1KDM4ECYP1A2HPGDBLM | |
| SCHEMBL9892413 | 0.81 | ALDH1A1 (0.67) | ALDH1A1KDM4ECYP1A2HPGDBLM | |
| SCHEMBL3307167 | 0.81 | ALDH1A1 (0.67) | ALDH1A1KDM4ECYP1A2HPGDBLM | |
| SCHEMBL3302369 | 0.81 | ALDH1A1 (0.67) | ALDH1A1KDM4ECYP1A2HPGDBLM | |
| SCHEMBL3975362 | 0.81 | ALDH1A1 (0.67) | ALDH1A1KDM4ECYP1A2HPGDBLM | |
| SCHEMBL10059376 | 0.80 | HSD17B10 (0.61) | ALDH1A1KDM4ECYP1A2HPGDBLM | |
| SCHEMBL10059326 | 0.80 | KDM4E (0.61) | ALDH1A1KDM4ECYP1A2HPGDBLM | |
| Pirfenidone SCHEMBL4708 | 0.80 | KDM4E (1.00) | ALDH1A1KDM4ECYP1A2HPGDBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 242 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12465605-B2 | Methods and materials for gender-dependent treatment of cardiovascular dysfunction | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2025-11-11 | — | — | US | claimed |
| WO-2025051889-A1 | ANTI PD-L2 ANTIBODIES FOR USE IN TREATING FIBROTIC DISEASES | REJUVERON SENESCENCE THERAPEUTICS AG (CH) | 2025-03-13 | — | — | WO | claimed |
| US-20240277682-A1 | PHARMACEUTICAL HYDRONIDONE FORMULATIONS FOR DISEASES | GYRE THERAPEUTICS, INC. | 2024-08-22 | — | — | US | claimed |
| EP-4326265-A1 | PHARMACEUTICAL HYDRONIDONE FORMULATIONS FOR DISEASES | Gyre Therapeutics, Inc. (US) | 2024-02-28 | — | — | EP | claimed |
| WO-2022221988-A1 | PHARMACEUTICAL HYDRONIDONE FORMULATIONS FOR DISEASES | SHANGHAI GENOMICS, INC. (CN) | 2022-10-27 | — | — | WO | claimed |
| US-20140249347-A1 | USE OF PYRIDONE DERIVATIVES IN THE PREVENTION OR TREATMENT OF TISSUE OR ORGAN TOXICITY INDUCED BY CYTOTOXIC AGENTS AND RADIATION | SHANGHAI GENOMICS, INC. (CN) | 2014-09-04 | — | — | US | claimed |
| US-8022087-B2 | Derivatives of pyridone and use thereof | Shangai Genomics, Inc. (CN) | 2011-09-20 | — | — | US | claimed |
| US-20110123495-A1 | DERIVATIVES OF PYRIDONE AND USE THEREOF | CATALYST BIOSCIENCES, INC. | 2011-05-26 | — | — | US | claimed |
| US-20080161361-A1 | e.g. 5-methyl-1-(4-hydroxylphenyl)-2-(1H)-pyridone; pirfenidone derivatives; enhancing therapeutic efficacy of cytotoxic agent, immunosuppressant, and radiation therapy; fibrosis of the kidney or lung, radiation pneumonitis, interstitial pneumonia; cancer: lung, bone marrow, breast, colon, pancreas | CATALYST BIOSCIENCES, INC. | 2008-07-03 | — | — | US | claimed |
| EP-4747359-A2 | HUMAN VASCULARIZED INTEGRATED ORGAN SYSTEM AND APPLICATIONS THEREOF | 3D Systems, Inc. (US) | 2026-05-27 | — | — | EP | disclosed |
| US-20260138998-A1 | GLP-1 RECEPTOR AGONISTS AND METHODS OF USE | MERCK SHARP & DOHME LLC (US) | 2026-05-21 | — | — | US | disclosed |
| US-20260137696-A1 | Compositions Comprising an Inhibitor of Galectin-3 | UNIVERSITY OF LIVERPOOL (GB) | 2026-05-21 | — | — | US | disclosed |
| EP-4739319-A1 | COMPOSITIONS COMPRISING AN INHIBITOR OF GALECTIN-3 | University of Liverpool (GB) | 2026-05-13 | — | — | EP | disclosed |
| EP-4739296-A1 | COMPOSITIONS COMPRISING AN INHIBITOR OF GALECTIN-3 | University of Liverpool (GB) | 2026-05-13 | — | — | EP | disclosed |
| WO-2007053685-A2 | METHODS OF TREATING ATRIAL FIBRILLATION WITH P38 INHIBITOR COMPOUNDS | INTERMUNE, INC. (US) | 2007-05-10 | — | — | WO | disclosed |
| US-20070049624-A1 | Derivatives of pyridone and the use of them | CATALYST BIOSCIENCES, INC. | 2007-03-01 | — | — | US | disclosed |
| US-20070049624-A1 | Derivatives of pyridone and the use of them | CATALYST BIOSCIENCES, INC. | 2007-03-01 | — | — | US | disclosed |
| US-20070049624-A1 | Derivatives of pyridone and the use of them | CATALYST BIOSCIENCES, INC. | 2007-03-01 | — | — | US | disclosed |
| CN-1878757-A | Pyridone derivatives and uses thereof | SHANGHAI GENOMICS INC (CN) | 2006-12-13 | — | — | CN | disclosed |
| EP-1683788-A1 | THE DERIVATIVES OF PYRIDONE AND THE USE OF THEM | Shanghai Genomics, Inc. (CN) | 2006-07-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140249347-A1 | USE OF PYRIDONE DERIVATIVES IN THE PREVENTION OR TREATMENT OF TISSUE OR ORGAN TOXICITY INDUCED BY CYTOTOXIC AGENTS AND RADIATION | PLPBP, PNPO, PIR | ALDH1A1 338/4885KDM4E 2486/4885CYP1A2 350/4885 |
| US-20260138998-A1 | GLP-1 RECEPTOR AGONISTS AND METHODS OF USE | GLP1R, GIPR, GPR119 | ALDH1A1 2405/4885KDM4E 2314/4885CYP1A2 2666/4885 |
| US-20110123495-A1 | DERIVATIVES OF PYRIDONE AND USE THEREOF | PNPO, PDXK, PLPBP | ALDH1A1 185/4885KDM4E 1239/4885CYP1A2 17/4885 |
| US-20080161361-A1 | e.g. 5-methyl-1-(4-hydroxylphenyl)-2-(1H)-pyridone; pirfenidone derivatives; enhancing therapeutic efficacy of cytotoxic agent, immunosuppressant, and radiation therapy; fibrosis of the kidney or lung, radiation pneumonitis, interstitial pneumonia; cancer: lung, bone marrow, breast, colon, pancreas | PIR, PDXK, BRCA1 | ALDH1A1 1541/4885KDM4E 302/4885CYP1A2 964/4885 |
| US-20070049624-A1 | Derivatives of pyridone and the use of them | PDXK, PNPO, PLPBP | ALDH1A1 206/4885KDM4E 995/4885CYP1A2 33/4885 |
| US-20240277682-A1 | PHARMACEUTICAL HYDRONIDONE FORMULATIONS FOR DISEASES | HYPK, SLC10A1, SYMPK | ALDH1A1 1427/4885KDM4E 4547/4885CYP1A2 855/4885 |
| US-20260137696-A1 | Compositions Comprising an Inhibitor of Galectin-3 | LGALS3, LGALS1, LGALS2 | ALDH1A1 2477/4885KDM4E 3734/4885CYP1A2 4162/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.