Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | ESRRG | P62508 | 2/20 | 0.35 |
| ▸ | ESRRB | O95718 | 1/20 | 0.35 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3579634 | 0.88 | SERPINE1 (0.40) | MEN1KMT2ASERPINE1LMNAHTT | |
| SCHEMBL3577185 | 0.87 | LMNA (0.40) | MEN1HPGDKMT2ALMNASMN1; SMN2 | |
| SCHEMBL3580209 | 0.85 | MCHR1 (0.40) | MEN1HPGDKMT2ANPSR1HDAC3 | |
| SCHEMBL3583661 | 0.82 | BTK (0.41) | MEN1KMT2AKCNH2HDAC3HDAC8 | |
| SCHEMBL3583634 | 0.81 | SERPINE1 (0.39) | MEN1KMT2ASERPINE1LMNAHTT | |
| SCHEMBL3576972 | 0.80 | BTK (0.36) | HDAC3HDAC8HDAC6NR1H4ESRRG | |
| SCHEMBL3584396 | 0.80 | C5AR1 (0.44) | MEN1KMT2ASERPINE1LMNAHTT | |
| SCHEMBL3581531 | 0.78 | C5AR1 (0.43) | MEN1KMT2ASERPINE1LMNAHTT | |
| SCHEMBL3569921 | 0.78 | SERPINE1 (0.47) | MEN1KMT2ASERPINE1LMNAHTT | |
| SCHEMBL3575452 | 0.78 | KMT2A (0.42) | MEN1KMT2ANR1H4ESRRGESRRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |