Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 3/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | ESRRG | P62508 | 2/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
| ▸ | CCR9 | P51686 | 1/20 | 0.34 |
| ▸ | ESRRB | O95718 | 1/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.34 |
| ▸ | MELK | Q14680 | 2/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3576972 | 0.92 | BTK (0.36) | BTKHDAC3HDAC8HDAC6ESRRG | |
| SCHEMBL3579944 | 0.91 | MCHR1 (0.39) | MCHR1CRHR1OPRM1OPRD1 | |
| SCHEMBL3576692 | 0.89 | ESRRG (0.37) | ESRRGNR1H4CCR9ESRRBOPRM1 | |
| SCHEMBL3583661 | 0.88 | BTK (0.41) | BTKHDAC3HDAC8HDAC6ESRRG | |
| SCHEMBL3586536 | 0.88 | MCHR1 (0.37) | MCHR1BTKHDAC3HDAC8HDAC6 | |
| SCHEMBL3585932 | 0.87 | CCR9 (0.36) | ESRRGNR1H4CCR9ESRRBOPRM1 | |
| SCHEMBL3577036 | 0.86 | MCHR1 (0.43) | MCHR1OPRM1OPRD1 | |
| SCHEMBL3570650 | 0.85 | CCR9 (0.41) | ESRRGNR1H4CCR9ESRRBNR1I3 | |
| SCHEMBL3572867 | 0.85 | MEN1 (0.38) | HDAC3HDAC8HDAC6ESRRGNR1H4 | |
| SCHEMBL3581265 | 0.85 | NR1H4 (0.39) | ESRRGNR1H4CCR9ESRRBOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |