Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.45 |
| ▸ | DAO | P14920 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 3/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | CA7 | P43166 | 3/20 | 0.41 |
| ▸ | CA13 | Q8N1Q1 | 3/20 | 0.41 |
| ▸ | GSR | P00390 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10732327 | 0.85 | FFAR1 (0.57) | ENPP2DAOALDH1A1GAACA1 | |
| SCHEMBL6208171 | 0.76 | PKM (0.58) | PKMALDH1A1GAACA2 | |
| SCHEMBL17285630 | 0.76 | FFAR1 (0.65) | PKMALDH1A1GAA | |
| SCHEMBL787870 | 0.76 | PKM (0.62) | PKMALDH1A1LMNA | |
| SCHEMBL1964022 | 0.76 | ALDH1A1 (0.58) | ALDH1A1GAACA1CA2CA7 | |
| SCHEMBL7876419 | 0.75 | CA2 (0.73) | PKMALDH1A1GAACA1CA2 | |
| SCHEMBL1269361 | 0.75 | TSHR (0.59) | PKMALDH1A1GAALMNA | |
| SCHEMBL3428545 | 0.75 | PKM (0.56) | PKMALDH1A1GAA | |
| SCHEMBL13113137 | 0.75 | PKM (0.51) | PKMALDH1A1GAALMNA | |
| SCHEMBL941105 | 0.75 | SMN1; SMN2 (0.66) | PKMALDH1A1GAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120178764-A1 | Novel Compounds | BONNERT ROGER (GB) | 2012-07-12 | — | — | US | disclosed |
| US-7687535-B2 | Substituted 3-sulfur indoles | ASTRAZENECA AB (SE) | 2010-03-30 | — | — | US | disclosed |
| US-20090163518-A1 | Novel Compounds | ASTRAZENECA AB (SE) | 2009-06-25 | — | — | US | disclosed |
| EP-2025670-A1 | 3-(Phenyl or quinolyl)thio-1H-indole-1-acetic acid derivatives as modulators of CRTh2 receptor activity | AstraZeneca AB (SE) | 2009-02-18 | — | — | EP | disclosed |
| US-20080249110-A1 | Novel Substituted 3-Sulfur Indoles | ASTRAZENECA AB (SE) | 2008-10-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178764-A1 | Novel Compounds | IDO1, IDO2, MTNR1A | PKM 2686/4885ENPP2 290/4885DAO 1266/4885 |
| US-20090163518-A1 | Novel Compounds | IDO1, IDO2, MTNR1A | PKM 2686/4885ENPP2 290/4885DAO 1266/4885 |
| US-20080249110-A1 | Novel Substituted 3-Sulfur Indoles | IDO1, IDO2, AANAT | PKM 3582/4885ENPP2 1806/4885DAO 1259/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.