Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | IDE | P14735 | 1/20 | 0.50 |
| ▸ | MPI | P34949 | 1/20 | 0.50 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.50 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | DAO | P14920 | 1/20 | 0.46 |
| ▸ | DDO | Q99489 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzoylenurea SCHEMBL29947820 | 1.00 | ALDH1A1 (0.58) | ALDH1A1KDM4EHSD17B10HPGDTSHR | |
| SCHEMBL554709 | 0.76 | KDM4E (0.58) | ALDH1A1KDM4EHSD17B10HPGDTSHR | |
| SCHEMBL6076792 | 0.76 | KDM4E (0.58) | ALDH1A1KDM4EHSD17B10HPGDTSHR | |
| SCHEMBL30293081 | 0.76 | ALDH1A1 (0.58) | ALDH1A1KDM4EHSD17B10HPGDTSHR | |
| SCHEMBL196018 | 0.76 | KDM4E (0.58) | ALDH1A1KDM4EHSD17B10HPGDTSHR | |
| SCHEMBL6099088 | 0.76 | KDM4E (0.58) | ALDH1A1KDM4EHSD17B10HPGDTSHR | |
| SCHEMBL4413903 | 0.76 | KDM4E (0.58) | ALDH1A1KDM4EHSD17B10HPGDTSHR | |
| SCHEMBL530191 | 0.76 | ALDH1A1 (0.58) | ALDH1A1KDM4EHSD17B10HPGDTSHR | |
| SCHEMBL3139711 | 0.76 | KDM4E (0.58) | ALDH1A1KDM4EHSD17B10HPGDTSHR | |
| SCHEMBL29844822 | 0.76 | KDM4E (0.58) | ALDH1A1KDM4EHSD17B10HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 94 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966476-B1 | Quinazolinone compounds | UNIV NEWCASTLE VENTURES LTD (GB) | 2002-09-04 | — | — | EP | claimed |
| US-6156739-A | Quinazolinone compounds | NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) | 2000-12-05 | — | — | US | claimed |
| EP-0966476-A1 | QUINAZOLINONE COMPOUNDS | NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) | 1999-12-29 | — | — | EP | claimed |
| WO-1998033802-A1 | QUINAZOLINONE COMPOUNDS | NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) | 1998-08-06 | — | — | WO | claimed |
| EP-4634171-A1 | PROCESS FOR THE PREPARATION OF A QUINAZOLINONE DERIVATIVE | F. Hoffmann-La Roche AG (CH) | 2025-10-22 | — | — | EP | disclosed |
| US-20250313551-A1 | PROCESS FOR THE PREPARATION OF A QUINAZOLINONE DERIVATIVE | HOFFMANN-LA ROCHE INC. (US) | 2025-10-09 | — | — | US | disclosed |
| WO-2024126634-A1 | PROCESS FOR THE PREPARATION OF A QUINAZOLINONE DERIVATIVE | F. HOFFMANN-LA ROCHE AG (CH) | 2024-06-20 | — | — | WO | disclosed |
| EP-3943494-A1 | QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | ICOS CORPORATION (US) | 2022-01-26 | — | — | EP | disclosed |
| US-20210332047-A1 | QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | ICOS CORP (US) | 2021-10-28 | — | — | US | disclosed |
| EP-3153514-B1 | QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | ICOS CORP (US) | 2021-04-21 | — | — | EP | disclosed |
| US-10906907-B2 | Tert-butyl (s)-(1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbamate precursor of a quinazolinone inhibitor of human phosphatidylinositol 3-kinase delta and a process for preparing thereof | ICOS CORPORATION (US) | 2021-02-02 | — | — | US | disclosed |
| US-10336756-B2 | (S)-2-(1-aminopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one precursor of a quinazolinone as inhibitor of human phosphatidylinositol 3-kinase delta | ICOS CORPORATION (US) | 2019-07-02 | — | — | US | disclosed |
| EP-0107398-B1 | ORTHO SUBSTITUTED DIHYDROXY-2(1H)QUINAZOLINONE-1-ALKANOIC ACIDS | ORTHO PHARMA CORP (US) | 1988-06-08 | — | — | EP | disclosed |
| US-4656267-A | RENAL VASODILATORS, CARDIOVASCULAR AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1987-04-07 | — | — | US | disclosed |
| US-4631283-A | RENAL VASODILATORS, CARDIOVASCULAR AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1986-12-23 | — | — | US | disclosed |
| US-4555571-A | Substituted 2(1H)-quinazolinone-1-alkanoic acids and esters | ORTHO PHARMACEUTICAL CORPORATION (US) | 1985-11-26 | — | — | US | disclosed |
| EP-0138491-A2 | Substituted 2(1H)-quinazolinone-1-alkanoic acids and esters | ORTHO PHARMACEUTICAL CORPORATION (US) | 1985-04-24 | — | — | EP | disclosed |
| US-4490374-A | CARDIOVASCULAR AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1984-12-25 | — | — | US | disclosed |
| EP-0107398-A1 | Ortho substituted dihydroxy-2(1H)quinazolinone-1-alkanoic acids | ORTHO PHARMACEUTICAL CORPORATION (US) | 1984-05-02 | — | — | EP | disclosed |
| US-4258187-A | REACTING 2-AMINO-BENZOPHENONE DERIVATIVES WITH A HYDROXYLAMINE SALT | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1981-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10336756-B2 | (S)-2-(1-aminopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one precursor of a quinazolinone as inhibitor of human phosphatidylinositol 3-kinase delta | PIK3CD, PIK3CA, PI4KA | ALDH1A1 3766/4885KDM4E 2553/4885HSD17B10 3452/4885 |
| US-20210332047-A1 | QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | PIK3CD, PIK3CA, PI4KA | ALDH1A1 4175/4885KDM4E 3421/4885HSD17B10 1773/4885 |
| US-10906907-B2 | Tert-butyl (s)-(1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbamate precursor of a quinazolinone inhibitor of human phosphatidylinositol 3-kinase delta and a process for preparing thereof | PIK3CD, PIK3CA, PIK3CB | ALDH1A1 4185/4885KDM4E 973/4885HSD17B10 3120/4885 |
| US-20250313551-A1 | PROCESS FOR THE PREPARATION OF A QUINAZOLINONE DERIVATIVE | NQO2, SDHA, NDUFS3 | ALDH1A1 1347/4885KDM4E 619/4885HSD17B10 2947/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.