Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN2 | P17706 | 1/20 | 0.61 |
| ▸ | PTPRB | P23467 | 1/20 | 0.61 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.61 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.53 |
| ▸ | ACLY | P53396 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27384808 | 0.82 | MAPK10 (0.63) | PTPN2PTPRBPTPN6MAPK10KDM4E | |
| SCHEMBL19494280 | 0.82 | PTK2 (0.68) | MAPK10ALDH1A1MAPK1KMT2AMEN1 | |
| SCHEMBL19237020 | 0.81 | PTPN2 (0.64) | PTPN2PTPRBPTPN6ABCC1ACLY | |
| SCHEMBL16838134 | 0.80 | KMT2A (0.63) | MAPK10KDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL1704195 | 0.80 | PTK2 (0.71) | PTPN2PTPRBPTPN6ABCC1ACLY | |
| SCHEMBL12756123 | 0.79 | PTPN2 (0.61) | PTPN2PTPRBPTPN6ABCC1ACLY | |
| SCHEMBL13764835 | 0.79 | PTPN2 (0.72) | PTPN2PTPRBPTPN6ABCC1ACLY | |
| SCHEMBL25381542 | 0.79 | PTPN2 (0.56) | PTPN2PTPRBPTPN6ABCC1ACLY | |
| SCHEMBL11866211 | 0.79 | PTK2 (0.42) | PTPN2PTPRBPTPN6ABCC1MAPK10 | |
| SCHEMBL23413590 | 0.77 | ACLY (0.57) | PTPN2PTPRBPTPN6ABCC1ACLY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| US-20230278978-A1 | THIOPHENE HSD17B13 INHIBITORS AND USES THEREOF | INIPHARM, INC. | 2023-09-07 | — | — | US | disclosed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |
| CN-101379036-B | Anthranilamide/2-amino-heteroarene carboxamide derivatives | HOFFMANN LA ROCHE | 2011-06-01 | — | — | CN | disclosed |
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | disclosed |
| CN-101379036-A | Anthranilamide/2-amino-heteroarene carboxamide derivatives | HOFFMANN LA ROCHE (CH) | 2009-03-04 | — | — | CN | disclosed |
| US-20080200468-A1 | 2-Substituted 5-Membered Heteroaryl Carboxylates as Hm74a Receptor Agonists | SMITHKLINE BEECHAM CORPORATION | 2008-08-21 | — | — | US | disclosed |
| EP-1853579-A2 | 2-SUBSTITUTED 5-MEMBERED HETEROARYL CARBOXYLATES AS HM74A RECEPTOR AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-11-14 | — | — | EP | disclosed |
| US-20070219261-A1 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. | 2007-09-20 | — | — | US | disclosed |
| WO-2006085113-A2 | 2-SUBSTITUTED 5-MEMBERED HETEROARYL CARBOXYLATES AS HM74A RECEPTOR AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-08-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070219261-A1 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | AADAT, AAAS, AADAC | PTPN2 3089/4885PTPRB 4635/4885PTPN6 4142/4885 |
| US-20230278978-A1 | THIOPHENE HSD17B13 INHIBITORS AND USES THEREOF | HSD17B3, HSD17B1, HSD17B13 | PTPN2 1631/4885PTPRB 1109/4885PTPN6 1501/4885 |
| US-20080200468-A1 | 2-Substituted 5-Membered Heteroaryl Carboxylates as Hm74a Receptor Agonists | GPR84, GPR88, HCAR1 | PTPN2 2379/4885PTPRB 3108/4885PTPN6 2501/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.