Sugi Predict

Sugi Predict / Compounds / SCHEMBL3577655

SCHEMBL3577655

SCHEMBL3577655

CCCC[Sn](CCCC)(CCCC)CCCC.[H-]

nearest known ligand 0.43

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ TSHR P16473 6/20 0.43
▸ LMNA P02545 3/20 0.43
▸ THRB P10828 1/20 0.40
▸ ALDH1A1 P00352 4/20 0.33
▸ TDP1 Q9NUW8 1/20 0.33
▸ OPRM1 P35372 1/20 0.32
▸ SLC22A1 O15245 3/20 0.32
▸ SLC22A2 O15244 1/20 0.32
▸ SMN1; SMN2 Q16637 1/20 0.32
▸ DNM1 Q05193 4/20 0.30
▸ HSD17B10 Q99714 1/20 0.30
▸ MEN1 O00255 1/20 0.30
▸ KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL135552 0.96 TSHR (0.46) TSHRLMNATHRBALDH1A1TDP1
SCHEMBL28438742 0.96 TSHR (0.46) TSHRLMNATHRBALDH1A1TDP1
Ammonia Solution, Strong SCHEMBL28759713 0.92 TSHR (0.43) TSHRLMNATHRBALDH1A1TDP1
Iodide SCHEMBL6657020 0.92 TSHR (0.43) TSHRLMNATHRBALDH1A1TDP1
SCHEMBL28092082 0.92 TSHR (0.43) TSHRLMNATHRBALDH1A1TDP1
Hydrochloric Acid SCHEMBL336735 0.92 TSHR (0.43) TSHRLMNATHRBALDH1A1TDP1
Water SCHEMBL3700992 0.92 TSHR (0.43) TSHRLMNATHRBALDH1A1TDP1
SCHEMBL863480 0.92 TSHR (0.43) TSHRLMNATHRBALDH1A1TDP1
SCHEMBL2139803 0.92 TSHR (0.43) TSHRLMNATHRBALDH1A1TDP1
Iodide SCHEMBL27498959 0.92 TSHR (0.43) TSHRLMNATHRBALDH1A1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110526903-B Bisindolylmaleimide derivative and preparation method and application thereof 中国海洋大学 2021-12-10 — — CN claimed
EP-0424833-B1 Reinforcing fibers coated with methathesis catalysts GOODRICH CO B F (US) 1996-01-03 — — EP claimed
EP-0424833-A2 Reinforcing fibers coated with methathesis catalysts THE B.F. GOODRICH COMPANY (US) 1991-05-02 — — EP claimed
CN-110770211-B Alpha, beta unsaturated amide compound 协和麒麟株式会社 2023-09-19 — — CN disclosed
CN-108430972-B Alpha, beta-unsaturated amide compound 协和麒麟株式会社 2022-12-27 — — CN disclosed
US-11332455-B2 α,β-unsaturated amide compound KYOWA KIRIN CO., LTD. (JP) 2022-05-17 — — US disclosed
CN-110218206-B Bisindolylmaleimide derivative and preparation method and application thereof 中国海洋大学 2022-03-04 — — CN disclosed
CN-110526903-B Bisindolylmaleimide derivative and preparation method and application thereof 中国海洋大学 2021-12-10 — — CN disclosed
US-20210380551-A1 ALPHA,BETA-UNSATURATED AMIDE COMPOUND KYOWA KIRIN CO., LTD. (JP) 2021-12-09 — — US disclosed
US-20210155612-A1 Alpha,Beta-UNSATURATED AMIDE COMPOUND KYOWA KIRIN CO., LTD. (JP) 2021-05-27 — — US disclosed
US-10787428-B2 α,β-unsaturated amide compound KYOWA KIRIN CO., LTD. (JP) 2020-09-29 — — US disclosed
CN-101193852-A 4-Hydroxyisoleucine analogs and uses thereof INNODIA INC (CA) 2008-06-04 — — CN disclosed
EP-1874287-A2 COMPOUNDS AND COMPOSITIONS FOR USE IN THE PREVENTION AND TREATMENT OF OBESITY AND RELATED SYNDROMES Innodia Inc. (CA) 2008-01-09 — — EP disclosed
EP-1858840-A2 ANALOGS OF 4-HYDROXYISOLEUCINE AND USES THEREOF Innodia Inc. (CA) 2007-11-28 — — EP disclosed
WO-2007107008-A1 COMPOUNDS AND COMPOSITIONS FOR USE IN THE PREVENTION AND TREATMENT OF DISORDERS OF FAT METABOLISM AND OBESITY INNODIA INC. (CA) 2007-09-27 — — WO disclosed
WO-2006131836-A2 COMPOUNDS AND COMPOSITIONS FOR USE IN THE PREVENTION AND TREATMENT OF OBESITY AND RELATED SYNDROMES INNODIA INC. (US) 2006-12-14 — — WO disclosed
WO-2006120574-A2 ANALOGS OF 4-HYDROXYISOLEUCINE AND USES THEREOF INNODIA INC. (CA) 2006-11-16 — — WO disclosed
US-20060223884-A1 Compounds and compositions for use in the prevention and treatment of obesity and related syndromes INVESTISSEMENT QUEBEC (CA) 2006-10-05 — — US disclosed
US-20060199853-A1 Analogs of 4-hydroxyisoleucine and uses thereof UNIVERSITE LOUIS PASTEUR STRASBOURG I (FR) 2006-09-07 — — US disclosed
EP-1152007-A1 ETHER TYPE LIPID A1-CARBOXYLIC ACID ANALOGUES Sankyo Company, Limited (JP) 2001-11-07 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210155612-A1 Alpha,Beta-UNSATURATED AMIDE COMPOUND NR1H2, NR1H3, RXRA TSHR 971/4885LMNA 1763/4885THRB 229/4885
US-20060223884-A1 Compounds and compositions for use in the prevention and treatment of obesity and related syndromes GPR119, HSD3B1, PC TSHR 3808/4885LMNA 770/4885THRB 1077/4885
US-20060199853-A1 Analogs of 4-hydroxyisoleucine and uses thereof GPR119, SLC2A1, SLC5A1 TSHR 2904/4885LMNA 964/4885THRB 1642/4885
US-10787428-B2 α,β-unsaturated amide compound NR1H2, NCOA1, NR0B1 TSHR 791/4885LMNA 2043/4885THRB 415/4885
US-20210380551-A1 ALPHA,BETA-UNSATURATED AMIDE COMPOUND NR1H2, NR1H3, NCOA1 TSHR 1080/4885LMNA 1785/4885THRB 303/4885
US-11332455-B2 α,β-unsaturated amide compound NR1H2, NCOA1, NR0B1 TSHR 791/4885LMNA 2043/4885THRB 415/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.