Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.39 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | CTSG | P08311 | 2/20 | 0.35 |
| ▸ | CMA1 | P23946 | 2/20 | 0.35 |
| ▸ | ERN1 | O75460 | 3/20 | 0.35 |
| ▸ | PRF1 | P14222 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16693080 | 0.85 | CYP2A6 (0.47) | CYP2A6ALDH1A1TSHRTRIM24TRIM33 | |
| SCHEMBL29942819 | 0.78 | CYP2A6 (0.52) | CYP2A6ALDH1A1TRIM24TRIM33ERN1 | |
| SCHEMBL4604059 | 0.78 | CYP2A6 (0.52) | CYP2A6ALDH1A1TRIM24TRIM33ERN1 | |
| SCHEMBL8404359 | 0.76 | CTSG (0.37) | CYP2A6ALDH1A1TSHRCTSGCMA1 | |
| SCHEMBL4605121 | 0.74 | CYP2A6 (0.47) | CYP2A6ERN1MEN1KMT2ATDP1 | |
| SCHEMBL4604201 | 0.74 | CYP2A6 (0.47) | CYP2A6ERN1MEN1KMT2ATDP1 | |
| SCHEMBL10372237 | 0.73 | ERN1 (0.50) | CYP2A6ALDH1A1TSHRERN1TDP1 | |
| SCHEMBL31722391 | 0.73 | CYP2A6 (0.46) | CYP2A6ERN1 | |
| SCHEMBL6327715 | 0.72 | ALDH1A1 (0.41) | CYP2A6ALDH1A1TSHRCTSGCMA1 | |
| SCHEMBL13888151 | 0.72 | CTSG (0.47) | CYP2A6ALDH1A1CTSGCMA1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074121-B1 | CHYMASE INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2016-11-30 | — | — | EP | disclosed |
| EP-2074121-B1 | CHYMASE INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2016-11-30 | — | — | EP | disclosed |
| US-8193214-B2 | Chymase inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-05 | — | — | US | disclosed |
| US-8193214-B2 | Chymase inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-05 | — | — | US | disclosed |
| US-8193214-B2 | Chymase inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-05 | — | — | US | disclosed |
| US-20100029637-A1 | Chymase Inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-02-04 | — | — | US | disclosed |
| US-20100029637-A1 | Chymase Inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-02-04 | — | — | US | disclosed |
| US-20100029637-A1 | Chymase Inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-02-04 | — | — | US | disclosed |
| US-20090299074-A1 | BENZO[b]THIOPHEN DERIVATIVES AND PROCESS FOR THEIR PRODUCTION | TEIJIN PHARMA LIMITED (JP) | 2009-12-03 | — | — | US | disclosed |
| US-20090299074-A1 | BENZO[b]THIOPHEN DERIVATIVES AND PROCESS FOR THEIR PRODUCTION | TEIJIN PHARMA LIMITED (JP) | 2009-12-03 | — | — | US | disclosed |
| EP-2074121-A1 | CHYMASE INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2009-07-01 | — | — | EP | disclosed |
| EP-1947097-A1 | BENZOÝb¨THIOPHEN DERIVATIVE AND PROCESS FOR PRODUCTION THEREOF | Teijin Pharma Limited (JP) | 2008-07-23 | — | — | EP | disclosed |
| EP-1947097-A1 | BENZOÝb¨THIOPHEN DERIVATIVE AND PROCESS FOR PRODUCTION THEREOF | Teijin Pharma Limited (JP) | 2008-07-23 | — | — | EP | disclosed |
| WO-2008045688-A1 | CHYMASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-04-17 | — | — | WO | disclosed |
| WO-2008045688-A1 | CHYMASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-04-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029637-A1 | Chymase Inhibitors | CMA1, CPA3, SERPINB1 | CYP2A6 3211/4885ALDH1A1 3399/4885TSHR 3397/4885 |
| US-20090299074-A1 | BENZO[b]THIOPHEN DERIVATIVES AND PROCESS FOR THEIR PRODUCTION | CMA1, TPSB2, CTRB1 | CYP2A6 244/4885ALDH1A1 1548/4885TSHR 2320/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.