Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ESRRG | P62508 | 3/20 | 0.39 |
| ▸ | ESRRB | O95718 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.35 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | XBP1 | P17861 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3578978 | 0.92 | CNR1 (0.43) | ESRRGESRRBSMN1; SMN2MEN1KMT2A | |
| SCHEMBL3577419 | 0.86 | NR1H4 (0.37) | MAPTTP53ESRRGESRRBMEN1 | |
| SCHEMBL3581360 | 0.85 | MCL1 (0.40) | SMN1; SMN2MEN1KMT2ALMNACNR1 | |
| SCHEMBL3583039 | 0.85 | CNR1 (0.43) | MAPTMCHR1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL3577052 | 0.83 | C5AR1 (0.37) | MAPTSMN1; SMN2MEN1KMT2AL3MBTL1 | |
| SCHEMBL3581545 | 0.82 | CNR1 (0.40) | CNR1LPAR1LPAR5NR1H4EPHX2 | |
| SCHEMBL3583628 | 0.80 | MCL1 (0.40) | SMN1; SMN2MEN1KMT2ALMNACNR1 | |
| SCHEMBL3589192 | 0.80 | PPARA (0.39) | SMN1; SMN2RCE1LPAR1LPAR5KDM4E | |
| SCHEMBL3580876 | 0.77 | LPAR1 (0.36) | SMN1; SMN2L3MBTL1RCE1CNR1LPAR1 | |
| SCHEMBL3582291 | 0.77 | MCL1 (0.39) | SMN1; SMN2MEN1KMT2ALMNACNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |