Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.74 |
| ▸ | MAPT | P10636 | 2/20 | 0.74 |
| ▸ | MEN1 | O00255 | 1/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.74 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.71 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.71 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.71 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.71 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.66 |
| ▸ | HTT | P42858 | 1/20 | 0.66 |
| ▸ | ESRRG | P62508 | 4/20 | 0.64 |
| ▸ | RAB9A | P51151 | 5/20 | 0.64 |
| ▸ | NPC1 | O15118 | 3/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13577905 | 0.95 | SMN1; SMN2 (0.81) | SMN1; SMN2ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL14615882 | 0.89 | RAB9A (0.68) | SMN1; SMN2ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL9490980 | 0.89 | SMN1; SMN2 (0.73) | SMN1; SMN2ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL28326194 | 0.89 | L3MBTL1 (0.73) | SMN1; SMN2ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL6359328 | 0.85 | MLYCD (0.66) | SMN1; SMN2ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL11960439 | 0.85 | SMN1; SMN2 (0.64) | SMN1; SMN2ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL17141782 | 0.83 | HDAC3 (1.00) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL13577906 | 0.83 | MLYCD (0.73) | SMN1; SMN2ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL15320627 | 0.83 | TMEM97 (0.61) | SMN1; SMN2ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL22919705 | 0.82 | L3MBTL1 (0.65) | SMN1; SMN2ALDH1A1HTTRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | disclosed |
| US-20070219261-A1 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. | 2007-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070219261-A1 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | AADAT, AAAS, AADAC | SMN1; SMN2 2333/4885ALDH1A1 1414/4885MAPT 2786/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.