Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CCR9 | P51686 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3576392 | 0.85 | HCRTR1 (0.38) | SERPINE1LMNACCR9HCRTR1HCRTR2 | |
| SCHEMBL3580080 | 0.80 | KLKB1 (0.36) | SERPINE1MAPTLMNACCR9CYP19A1 | |
| SCHEMBL3577510 | 0.78 | SERPINE1 (0.36) | SERPINE1MAPTLMNACCR9CYP19A1 | |
| SCHEMBL3584396 | 0.78 | C5AR1 (0.44) | SERPINE1LMNACCR9ALDH1A1HTT | |
| SCHEMBL3581532 | 0.78 | RAB9A (0.41) | SERPINE1MAPTCCR9ALDH1A1MEN1 | |
| SCHEMBL3569719 | 0.77 | SERPINE1 (0.40) | SERPINE1LMNACCR9NR1H4ALDH1A1 | |
| SCHEMBL3574965 | 0.76 | ALDH1A1 (0.38) | SERPINE1CRHR1CCR9ALDH1A1CYP1A2 | |
| SCHEMBL3580741 | 0.76 | C5AR1 (0.40) | SERPINE1LMNACCR9NR1H4ALDH1A1 | |
| SCHEMBL3577474 | 0.76 | CCR9 (0.35) | SERPINE1CRHR1LMNACCR9CYP19A1 | |
| SCHEMBL3578962 | 0.76 | CCR1 (0.37) | SERPINE1MAPTLMNACCR9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |