Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 9/20 | 0.64 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.64 |
| ▸ | GSK3B | P49841 | 6/20 | 0.64 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.64 |
| ▸ | GSK3A | P49840 | 5/20 | 0.64 |
| ▸ | RPS6KA5 | O75582 | 5/20 | 0.64 |
| ▸ | PRKG1 | Q13976 | 5/20 | 0.64 |
| ▸ | PKN2 | Q16513 | 5/20 | 0.64 |
| ▸ | PRKACA | P17612 | 4/20 | 0.64 |
| ▸ | PRKX | P51817 | 4/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.64 |
| ▸ | SGK2 | Q9HBY8 | 4/20 | 0.64 |
| ▸ | AKT1 | P31749 | 4/20 | 0.64 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.64 |
| ▸ | PRKG2 | Q13237 | 4/20 | 0.64 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.64 |
| ▸ | PRKCG | P05129 | 3/20 | 0.64 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.64 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.64 |
| ▸ | CDC42BPA | Q5VT25 | 3/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2247163 | 0.97 | MMP13 (0.65) | ROCK1ROCK2GSK3BCLK4GSK3A | |
| SCHEMBL3576509 | 0.93 | ADAMTS5 (0.62) | ROCK1ROCK2GSK3BCLK4GSK3A | |
| SCHEMBL3584207 | 0.90 | CTSB (0.53) | ROCK1ROCK2GSK3BCLK4GSK3A | |
| SCHEMBL3579414 | 0.89 | ADAMTS5 (0.57) | ADAMTS5ADAMTS4KDM1AMAOACTSS | |
| SCHEMBL2247866 | 0.88 | ADAMTS5 (0.56) | ADAMTS5ADAMTS4KDM1AMAOACTSS | |
| SCHEMBL2252325 | 0.87 | ADAMTS5 (0.53) | ROCK1ROCK2GSK3BCLK4GSK3A | |
| SCHEMBL3586210 | 0.87 | ADAMTS5 (0.58) | ADAMTS5ADAMTS4KDM1AMAOACTSS | |
| SCHEMBL3584878 | 0.86 | CTSL (0.54) | ADAMTS5ADAMTS4KDM1AMAOACTSS | |
| SCHEMBL2249522 | 0.86 | ADAMTS5 (0.54) | ADAMTS5ADAMTS4KDM1AMAOACTSS | |
| SCHEMBL2245585 | 0.85 | ADAMTS5 (0.56) | ADAMTS5ADAMTS4KDM1AMAOACTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070043066-A1 | Glutamate aggrecanase inhibitors | WYETH (US) | 2007-02-22 | — | — | US | claimed |
| US-20100010012-A1 | GLUTAMATE AGGRECANASE INHIBITORS | WYETH (US) | 2010-01-14 | — | — | US | disclosed |
| US-7553873-B2 | Glutamate aggrecanase inhibitors | WYETH (US) | 2009-06-30 | — | — | US | disclosed |
| US-20070043066-A1 | Glutamate aggrecanase inhibitors | WYETH (US) | 2007-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100010012-A1 | GLUTAMATE AGGRECANASE INHIBITORS | ADAMTS5, ADAMTS1, ADAMTS7 | ROCK1 3011/4885ROCK2 3155/4885GSK3B 2399/4885 |
| US-20070043066-A1 | Glutamate aggrecanase inhibitors | ADAMTS5, ADAMTS1, ADAMTS7 | ROCK1 3011/4885ROCK2 3155/4885GSK3B 2399/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.