Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | AR | P10275 | 3/20 | 0.49 |
| ▸ | CTSS | P25774 | 2/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | PRKACA | P17612 | 4/20 | 0.45 |
| ▸ | PRKACG | P22612 | 4/20 | 0.45 |
| ▸ | PRKACB | P22694 | 4/20 | 0.45 |
| ▸ | KIF11 | P52732 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | XDH | P47989 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | NAAA | Q02083 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2167740 | 0.85 | KIF11 (0.57) | KDM4EALDH1A1ARPRKACAPRKACG | |
| SCHEMBL25983833 | 0.82 | CTSS (0.53) | KDM4EALDH1A1GAAARCTSS | |
| SCHEMBL165877 | 0.81 | ALOX5AP (0.44) | KDM4EALDH1A1GAAARKIF11 | |
| SCHEMBL29646422 | 0.81 | ALOX5AP (0.44) | KDM4EALDH1A1GAAARKIF11 | |
| SCHEMBL115693 | 0.80 | MAOB (0.54) | ALDH1A1GAAMAOBKDM1AKIF11 | |
| SCHEMBL5072719 | 0.79 | TDP1 (0.48) | KDM4EALDH1A1GAAARPRKACA | |
| SCHEMBL3879887 | 0.79 | TAAR1 (0.55) | KDM4EARPRKACAPRKACGPRKACB | |
| SCHEMBL9205171 | 0.78 | CYP11B2 (0.50) | KDM4EALDH1A1GAAARCTSS | |
| SCHEMBL5302056 | 0.78 | MCL1 (0.50) | KDM4EALDH1A1GAAPRKACAPRKACG | |
| SCHEMBL25983856 | 0.77 | AR (0.51) | KDM4EALDH1A1GAAARCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7691891-B2 | Diphenylurea derivatives and their use as chloride channel blockers | NEUROSEARCH A/S (DK) | 2010-04-06 | — | — | US | disclosed |
| EP-1638948-B1 | DIPHENYLUREA DERIVATIVES AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS | NEUROSEARCH AS (DK) | 2008-10-15 | — | — | EP | disclosed |
| US-20070293553-A1 | Diphenylurea Derivatives Useful As Potassium Channel Activators | NEUROSEARCH A/S (DK) | 2007-12-20 | — | — | US | disclosed |
| EP-1827411-A2 | DIPHENYLUREA DERIVATIVES USEFUL AS POTASSIUM CHANNEL ACTIVATORS | NEUROSEARCH A/S (DK) | 2007-09-05 | — | — | EP | disclosed |
| US-20060178413-A1 | Diphenylurea derivatives and their use as chloride channel blockers | NEUSEARCH A/S (DK) | 2006-08-10 | — | — | US | disclosed |
| WO-2006064015-A2 | DIPHENYLUREA DERIVATIVES USEFUL AS POTASSIUM CHANNEL ACTIVATORS | NEUROSEARCH A/S (DK) | 2006-06-22 | — | — | WO | disclosed |
| EP-1638948-A1 | DIPHENYLUREA DERIVATIVES AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS | NEUROSEARCH A/S (DK) | 2006-03-29 | — | — | EP | disclosed |
| WO-2004111017-A1 | DIPHENYLUREA DERIVATIVES AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS | NEUROSEARCH A/S (DK) | 2004-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070293553-A1 | Diphenylurea Derivatives Useful As Potassium Channel Activators | KCNJ2, KCNH2, KCNH3 | KDM4E 604/4885ALDH1A1 418/4885GAA 1448/4885 |
| US-20060178413-A1 | Diphenylurea derivatives and their use as chloride channel blockers | CLIC1, CLIC4, CLCN2 | KDM4E 2482/4885ALDH1A1 1167/4885GAA 2528/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.