Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 4/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13072197 | 0.87 | PTGS1 (0.36) | PTGS1PTGS2GPR119ALDH1A1KDM4E | |
| SCHEMBL3591383 | 0.86 | ALDH1A1 (0.37) | GPR119ALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL3581546 | 0.84 | KDM4E (0.36) | GPR119ALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL3588558 | 0.83 | PTGS1 (0.37) | PTGS1PTGS2ALOX5 | |
| SCHEMBL3587927 | 0.83 | ALDH1A1 (0.38) | GPR119ALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL3587938 | 0.80 | GRIN2B (0.40) | GPR119ALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL2297608 | 0.79 | CCR5 (0.43) | ALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL3591327 | 0.78 | ENPP2 (0.41) | ALDH1A1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL3590433 | 0.78 | TRPC3 (0.40) | ALDH1A1KDM4EHSD17B10HPGDL3MBTL1 | |
| SCHEMBL3593203 | 0.77 | CPT1A (0.44) | ALDH1A1KDM4EHSD17B10HPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100286191-A1 | 2-Arylthiazole Derivatives as CXCR3 Receptor Modulators | MERCK SHARP & DOHME CORP. | 2010-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286191-A1 | 2-Arylthiazole Derivatives as CXCR3 Receptor Modulators | CXCR3, CXCR1, CXCR2 | PTGS1 190/4885PTGS2 311/4885GPR119 161/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.