Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR4 | O00206 | 3/20 | 0.33 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7538188 | 0.83 | ITGB3 (0.34) | MT-CO2ALOX5 | |
| SCHEMBL6023505 | 0.78 | CYP2D6 (0.37) | — | |
| SCHEMBL3327529 | 0.76 | — | — | |
| SCHEMBL14101011 | 0.73 | NOS2 (0.30) | — | |
| SCHEMBL14169479 | 0.73 | NOS1 (0.38) | — | |
| SCHEMBL14635516 | 0.72 | — | — | |
| SCHEMBL4869060 | 0.72 | METAP1 (0.34) | — | |
| SCHEMBL3325656 | 0.72 | PDK1 (0.32) | — | |
| SCHEMBL16503645 | 0.71 | TLR4 (0.36) | TLR4MT-CO2ALOX5 | |
| SCHEMBL1397437 | 0.71 | NPC1 (0.45) | TLR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8674115-B2 | CRTH2 modulators | IRONWOOD PHARMACEUTICALS, INC. (US) | 2014-03-18 | — | — | US | disclosed |
| US-8674115-B2 | CRTH2 modulators | IRONWOOD PHARMACEUTICALS, INC. (US) | 2014-03-18 | — | — | US | disclosed |
| US-8674115-B2 | CRTH2 modulators | IRONWOOD PHARMACEUTICALS, INC. (US) | 2014-03-18 | — | — | US | disclosed |
| US-20130259830-A1 | CRTH2 MODULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2013-10-03 | — | — | US | disclosed |
| US-20130259830-A1 | CRTH2 MODULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2013-10-03 | — | — | US | disclosed |
| US-20130259830-A1 | CRTH2 MODULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2013-10-03 | — | — | US | disclosed |
| EP-2516416-A1 | CRTH2 MODULATORS | Ironwood Pharmaceuticals, Inc. (US) | 2012-10-31 | — | — | EP | disclosed |
| WO-2012009134-A1 | CRTH2 MODULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2012-01-19 | — | — | WO | disclosed |
| WO-2012009134-A1 | CRTH2 MODULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2012-01-19 | — | — | WO | disclosed |
| WO-2011079007-A1 | CRTH2 MODULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-30 | — | — | WO | disclosed |
| WO-2011079007-A1 | CRTH2 MODULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-30 | — | — | WO | disclosed |
| US-20110150834-A1 | CRTH2 MODULATORS | WELLS FARGO BANK, NATIONAL ASSOCIATION | 2011-06-23 | — | — | US | disclosed |
| US-20110150834-A1 | CRTH2 MODULATORS | WELLS FARGO BANK, NATIONAL ASSOCIATION | 2011-06-23 | — | — | US | disclosed |
| US-20110150834-A1 | CRTH2 MODULATORS | WELLS FARGO BANK, NATIONAL ASSOCIATION | 2011-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110150834-A1 | CRTH2 MODULATORS | HRH2, HRH1, NR1H2 | TLR4 2387/4885MT-CO2 981/4885ALOX5 515/4885 |
| US-20130259830-A1 | CRTH2 MODULATORS | HRH2, HRH1, NR1H2 | TLR4 2387/4885MT-CO2 981/4885ALOX5 515/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.