Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 3/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | CCR5 | P51681 | 11/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.41 |
| ▸ | TACR2 | P21452 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3597050 | 0.92 | CCR5 (0.46) | SLC6A4DRD2CCR5KCNH2TACR2 | |
| SCHEMBL3610524 | 0.83 | CCR5 (0.58) | SLC6A4DRD2CCR5KCNH2TACR2 | |
| SCHEMBL5858734 | 0.79 | CCR5 (0.52) | SLC6A4DRD2CCR5TACR2 | |
| SCHEMBL5857199 | 0.77 | DRD2 (0.49) | SLC6A4DRD2CCR5TACR2PKM | |
| SCHEMBL3596577 | 0.76 | DRD2 (0.48) | SLC6A4DRD2CCR5TACR2PKM | |
| SCHEMBL3589931 | 0.76 | SLC6A4 (0.48) | SLC6A4DRD2CCR5TACR2SLC6A2 | |
| SCHEMBL5451946 | 0.71 | CCR5 (0.58) | CCR5KCNH2 | |
| SCHEMBL5451951 | 0.71 | CCR5 (0.58) | CCR5KCNH2 | |
| SCHEMBL5857960 | 0.70 | DRD2 (0.54) | SLC6A4DRD2CCR5TACR2 | |
| SCHEMBL5858616 | 0.69 | DRD2 (0.69) | SLC6A4DRD2CCR5TACR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100010007-A1 | PIPERIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR CCR5 | ASTRAZENECA AB (SE) | 2010-01-14 | — | — | US | disclosed |
| US-20070167442-A1 | Chemical compounds | ASTRAZENECA AB (SE) | 2007-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100010007-A1 | PIPERIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR CCR5 | CCR5, CCR2, CXCR3 | SLC6A4 1423/4885DRD2 608/4885CCR5 1/4885 |
| US-20070167442-A1 | Chemical compounds | CCR5, CXCR3, CX3CR1 | SLC6A4 1243/4885DRD2 938/4885CCR5 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.