Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 13/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3598803 | 0.82 | ROCK2 (0.34) | ROCK2 | |
| SCHEMBL3603138 | 0.78 | HDAC8 (0.48) | HDAC8 | |
| SCHEMBL3615681 | 0.77 | HDAC8 (0.37) | HDAC8 | |
| SCHEMBL3603140 | 0.75 | GHSR (0.37) | HDAC8 | |
| SCHEMBL3615682 | 0.72 | FKBP1A (0.31) | — | |
| SCHEMBL3600884 | 0.69 | ROCK2 (0.35) | ROCK2 | |
| SCHEMBL3608110 | 0.64 | GHSR (0.39) | HDAC8 | |
| SCHEMBL8864481 | 0.63 | HSD17B10 (0.46) | BLM | |
| SCHEMBL3614238 | 0.63 | ROCK2 (0.37) | ROCK2 | |
| SCHEMBL25014907 | 0.62 | PTPN1 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100022582-A1 | Tetrahydroisoquinoline Compound and Medicinal Use Thereof | KYOTO PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2010-01-28 | — | — | US | disclosed |
| EP-1857444-A1 | TETRAHYDROISOQUINOLINE COMPOUND AND MEDICINAL USE THEREOF | Kyoto Pharmaceutical Industries, Ltd. (JP) | 2007-11-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022582-A1 | Tetrahydroisoquinoline Compound and Medicinal Use Thereof | ACAT1, ACAT2, LCAT | HDAC8 375/4885ROCK2 1017/4885BLM 3191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.