Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.41 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.41 |
| ▸ | ACAT1 | P24752 | 1/20 | 0.41 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 2/20 | 0.39 |
| ▸ | GHSR | Q92847 | 6/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | F11 | P03951 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3617469 | 0.83 | ACE (0.43) | SOAT2ACAT1SOAT1GHSRF11 | |
| SCHEMBL3608890 | 0.80 | OPRM1 (0.44) | SOAT2ACAT1SOAT1BCHEACHE | |
| Hydrochloric Acid SCHEMBL3606029 | 0.79 | OPRM1 (0.44) | SOAT2ACAT1SOAT1BCHEACHE | |
| SCHEMBL3601495 | 0.77 | XIAP (0.45) | F11 | |
| SCHEMBL3609076 | 0.77 | GHSR (0.39) | HSP90AA1HSP90AB1BCHEACHENAMPT | |
| SCHEMBL3616236 | 0.74 | RORC (0.39) | SOAT2ACAT1SOAT1GHSR | |
| SCHEMBL3615625 | 0.74 | GHSR (0.42) | HSP90AA1HSP90AB1BCHEACHENAMPT | |
| SCHEMBL3607582 | 0.73 | RORC (0.37) | SOAT2ACAT1SOAT1F11 | |
| Hydrochloric Acid SCHEMBL3611410 | 0.72 | RORC (0.36) | SOAT2ACAT1SOAT1F11 | |
| SCHEMBL3611181 | 0.72 | PPARD (0.44) | SOAT2ACAT1SOAT1GHSRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100022582-A1 | Tetrahydroisoquinoline Compound and Medicinal Use Thereof | KYOTO PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2010-01-28 | — | — | US | disclosed |
| EP-1857444-A1 | TETRAHYDROISOQUINOLINE COMPOUND AND MEDICINAL USE THEREOF | Kyoto Pharmaceutical Industries, Ltd. (JP) | 2007-11-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022582-A1 | Tetrahydroisoquinoline Compound and Medicinal Use Thereof | ACAT1, ACAT2, LCAT | HSP90AA1 1891/4885HSP90AB1 1569/4885SOAT2 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.