Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 14/20 | 0.58 |
| ▸ | CDK2 | P24941 | 9/20 | 0.58 |
| ▸ | MTOR | P42345 | 6/20 | 0.58 |
| ▸ | SMG1 | Q96Q15 | 5/20 | 0.58 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.56 |
| ▸ | CDK9 | P50750 | 10/20 | 0.50 |
| ▸ | CCNT1 | O60563 | 9/20 | 0.50 |
| ▸ | CCNB1 | P14635 | 9/20 | 0.50 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.50 |
| ▸ | CDK7 | P50613 | 5/20 | 0.50 |
| ▸ | CCNH | P51946 | 5/20 | 0.50 |
| ▸ | CCNA1 | P78396 | 5/20 | 0.50 |
| ▸ | IKBKB | O14920 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 2/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | MET | P08581 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3609726 | 0.92 | CDK9 (0.59) | CDK1CDK2MTORSMG1SLC2A1 | |
| SCHEMBL3609785 | 0.88 | CDK1 (0.56) | CDK1CDK2MTORSMG1SLC2A1 | |
| SCHEMBL3600662 | 0.85 | SLC2A1 (0.51) | CDK1CDK2MTORSMG1SLC2A1 | |
| SCHEMBL3603990 | 0.84 | CAMK2D (0.60) | CDK1CDK2MTORSMG1CDK9 | |
| SCHEMBL3610465 | 0.82 | CAMK2D (0.60) | CDK1CDK2MTORSMG1CDK9 | |
| SCHEMBL3602838 | 0.82 | CDK4 (0.54) | CDK1CDK2SMG1IKBKBABL1 | |
| SCHEMBL5996833 | 0.80 | ABL1 (0.58) | IKBKBABL1AURKAPDGFRBMAPK8 | |
| SCHEMBL3600716 | 0.79 | ABL1 (0.55) | CDK1CDK2MTORSMG1SLC2A1 | |
| SCHEMBL3612180 | 0.78 | CAMK2D (0.69) | CDK1CDK2MTORSMG1CDK9 | |
| SCHEMBL14140620 | 0.78 | ABL1 (0.50) | CDK1CDK2MTORSMG1SLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100022582-A1 | Tetrahydroisoquinoline Compound and Medicinal Use Thereof | KYOTO PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2010-01-28 | — | — | US | claimed |
| EP-1857444-A1 | TETRAHYDROISOQUINOLINE COMPOUND AND MEDICINAL USE THEREOF | Kyoto Pharmaceutical Industries, Ltd. (JP) | 2007-11-21 | — | — | EP | claimed |
| US-20100048597-A1 | Organic Compounds and Their Uses | NOVARTIS AG | 2010-02-25 | — | — | US | disclosed |
| US-20100048597-A1 | Organic Compounds and Their Uses | NOVARTIS AG | 2010-02-25 | — | — | US | disclosed |
| US-20100048597-A1 | Organic Compounds and Their Uses | NOVARTIS AG | 2010-02-25 | — | — | US | disclosed |
| US-20100022582-A1 | Tetrahydroisoquinoline Compound and Medicinal Use Thereof | KYOTO PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2010-01-28 | — | — | US | disclosed |
| WO-2008079933-A2 | HETEROARYL-HETEROARYL COMPOUNDS AS CDK INHIBITORS FOR THE TREATMENT OF CANCER, INFLAMMATION AND VIRAL INFECTIONS | NOVARTIS AG (CH) | 2008-07-03 | — | — | WO | disclosed |
| EP-1857444-A1 | TETRAHYDROISOQUINOLINE COMPOUND AND MEDICINAL USE THEREOF | Kyoto Pharmaceutical Industries, Ltd. (JP) | 2007-11-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022582-A1 | Tetrahydroisoquinoline Compound and Medicinal Use Thereof | ACAT1, ACAT2, LCAT | CDK1 4024/4885CDK2 2526/4885MTOR 1537/4885 |
| US-20100048597-A1 | Organic Compounds and Their Uses | OAT, OTC, AOX1 | CDK1 3769/4885CDK2 3078/4885MTOR 4191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.