Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.56 |
| ▸ | VCP | P55072 | 1/20 | 0.52 |
| ▸ | CFTR | P13569 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 6/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14458516 | 0.87 | ALOX5 (0.72) | MAPTALDH1A1KDM4ETDP1ALOX5 | |
| SCHEMBL837871 | 0.80 | MEN1 (0.64) | MAPTALDH1A1KDM4ETDP1ALOX5 | |
| SCHEMBL12298086 | 0.79 | CFTR (0.64) | MAPTKDM4EALOX5VCPCFTR | |
| SCHEMBL3607273 | 0.79 | MAPT (0.58) | MAPTALDH1A1KDM4ETDP1ALOX5 | |
| SCHEMBL23742654 | 0.79 | VCP (0.58) | MAPTKDM4EALOX5VCPCFTR | |
| SCHEMBL4080677 | 0.79 | ALOX5 (0.70) | MAPTALDH1A1KDM4EALOX5VCP | |
| SCHEMBL12136771 | 0.79 | RAB9A (0.77) | MAPTALDH1A1KDM4ETDP1MEN1 | |
| SCHEMBL6115386 | 0.76 | KDM4E (0.41) | MAPTALDH1A1KDM4ETDP1ALOX5 | |
| SCHEMBL12136708 | 0.76 | MAPT (0.72) | MAPTALDH1A1KDM4ETDP1CFTR | |
| SCHEMBL12136779 | 0.74 | MAPT (1.00) | MAPTALDH1A1KDM4ETDP1CFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100022592-A1 | THIAZOLE DERIVATIVES AS MODULATORS OF G PROTEIN-COUPLED RECEPTORS | IRM LLC (BM) | 2010-01-28 | — | — | US | disclosed |
| US-20100022592-A1 | THIAZOLE DERIVATIVES AS MODULATORS OF G PROTEIN-COUPLED RECEPTORS | IRM LLC (BM) | 2010-01-28 | — | — | US | disclosed |
| EP-2121675-A1 | THIAZOLE DERIVATIVES AS MODULATORS OF G PROTEIN-COUPLED RECEPTORS | IRM LLC (BM) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008103500-A1 | THIAZOLE DERIVATIVES AS MODULATORS OF G PROTEIN-COUPLED RECEPTORS | IRM LLC (BM) | 2008-08-28 | — | — | WO | disclosed |
| WO-2008103500-A1 | THIAZOLE DERIVATIVES AS MODULATORS OF G PROTEIN-COUPLED RECEPTORS | IRM LLC (BM) | 2008-08-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022592-A1 | THIAZOLE DERIVATIVES AS MODULATORS OF G PROTEIN-COUPLED RECEPTORS | GPR119, GPR65, GPR180 | MAPT 3596/4885ALDH1A1 1885/4885KDM4E 4170/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.