Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | TAS2R8 | Q9NYW2 | 2/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | NAMPT | P43490 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3608690 | 0.89 | TAS2R8 (0.52) | ALDH1A1TAS2R8ROCK2SMN1; SMN2NAMPT | |
| SCHEMBL3611274 | 0.88 | NAMPT (0.56) | NAMPT | |
| SCHEMBL13504884 | 0.88 | NAMPT (0.60) | ALDH1A1NAMPTRPS6KA2 | |
| SCHEMBL3611305 | 0.87 | NAMPT (0.63) | ALDH1A1TAS2R8ROCK2SMN1; SMN2NAMPT | |
| Hydrochloric Acid SCHEMBL3612494 | 0.87 | NAMPT (0.59) | ALDH1A1NAMPTRPS6KA2 | |
| SCHEMBL13504905 | 0.85 | ITK (0.59) | ALDH1A1TAS2R8ROCK2NAMPTCYP3A4 | |
| SCHEMBL3608825 | 0.85 | SCD5 (0.53) | ALDH1A1ROCK2SMN1; SMN2NAMPTCYP1A2 | |
| Hydrochloric Acid SCHEMBL3600325 | 0.85 | ITK (0.58) | ALDH1A1TAS2R8ROCK2NAMPTCYP3A4 | |
| SCHEMBL3606398 | 0.84 | SMN1; SMN2 (0.52) | ALDH1A1SMN1; SMN2NAMPTPLA2G1BCYP1A2 | |
| SCHEMBL3602522 | 0.83 | SMN1; SMN2 (0.60) | SMN1; SMN2NAMPTHPGDKDM4EPLA2G1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100041696-A1 | Compounds | SMITHKLINE BEECHAM CORPORATION | 2010-02-18 | — | — | US | claimed |
| US-20160207938-A1 | QUINAZOLINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2016-07-21 | — | — | US | disclosed |
| US-9273013-B2 | Quinazoline derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2016-03-01 | — | — | US | disclosed |
| US-20130178624-A1 | QUINAZOLINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2013-07-11 | — | — | US | disclosed |
| US-8394786-B2 | Quinazoline derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2013-03-12 | — | — | US | disclosed |
| US-20100105668-A1 | Quinazoline derivatives | FREYNE EDDY JEAN EDGARD | 2010-04-29 | — | — | US | disclosed |
| US-20100041696-A1 | Compounds | SMITHKLINE BEECHAM CORPORATION | 2010-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130178624-A1 | QUINAZOLINE DERIVATIVES | NR1H2, NR1H3, NR3C2 | ALDH1A1 2807/4885TAS2R8 2724/4885ROCK2 3049/4885 |
| US-20100041696-A1 | Compounds | CYP11B2, SCD, CYP3A5 | ALDH1A1 430/4885TAS2R8 3530/4885ROCK2 2385/4885 |
| US-20100105668-A1 | Quinazoline derivatives | NR1H2, NR1H3, NR3C2 | ALDH1A1 2784/4885TAS2R8 2551/4885ROCK2 3089/4885 |
| US-20160207938-A1 | QUINAZOLINE DERIVATIVES | NR1H2, NR1H3, NR3C2 | ALDH1A1 2932/4885TAS2R8 2268/4885ROCK2 3039/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.