Sugi Predict

Sugi Predict / Compounds / SCHEMBL360736

SCHEMBL360736

SCHEMBL360736

Nc1nc2cc(Br)cnc2s1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HTT P42858 2/20 0.41
▸ KMT2A Q03164 1/20 0.41
▸ NSD1 Q96L73 1/20 0.40
▸ DYRK1A Q13627 3/20 0.37
▸ SMN1; SMN2 Q16637 2/20 0.36
▸ ALDH1A1 P00352 1/20 0.36
▸ TP53 P04637 1/20 0.36
▸ CYP3A4 P08684 1/20 0.36
▸ TSHR P16473 1/20 0.36
▸ MAPT P10636 1/20 0.34
▸ RAB9A P51151 1/20 0.34
▸ AXL P30530 1/20 0.34
▸ GFER P55789 1/20 0.34
▸ GAA P10253 1/20 0.34
▸ L3MBTL1 Q9Y468 1/20 0.34
▸ PIK3CD O00329 4/20 0.34
▸ PI4KA P42356 4/20 0.34
▸ PI4KB Q9UBF8 4/20 0.34
▸ PIK3CG P48736 3/20 0.34
▸ PIK3CA P42336 3/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8472326 0.80 SMN1; SMN2 (0.38) HTTSMN1; SMN2ALDH1A1TP53CYP3A4
SCHEMBL16476934 0.77 SMN1; SMN2 (0.41) HTTKMT2ADYRK1ASMN1; SMN2ALDH1A1
SCHEMBL359349 0.77 DYRK1A (0.36) HTTKMT2ADYRK1ASMN1; SMN2ALDH1A1
SCHEMBL19329221 0.77 ALDH1A1 (0.38) HTTSMN1; SMN2ALDH1A1TP53CYP3A4
SCHEMBL359702 0.77 SMN1; SMN2 (0.36) HTTSMN1; SMN2ALDH1A1TP53CYP3A4
SCHEMBL368903 0.77 AXL (0.46) HTTSMN1; SMN2ALDH1A1TP53CYP3A4
SCHEMBL15241061 0.77 UBE2T (0.40) HTTKMT2ADYRK1ASMN1; SMN2ALDH1A1
SCHEMBL2706690 0.74 DYRK1A (0.34) HTTKMT2ADYRK1ASMN1; SMN2ALDH1A1
SCHEMBL30995460 0.73 NPSR1 (0.39) HTTKMT2ADYRK1ASMN1; SMN2ALDH1A1
SCHEMBL15713825 0.73 DYRK1A (0.33) HTTDYRK1ASMN1; SMN2ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4634170-A1 IMIDAZO[4,5-B]PYRIDINE DERIVATIVES AS PCSK9 INHIBITORS AND METHODS OF USE THEREOF AstraZeneca AB (SE) 2025-10-22 — — EP disclosed
CN-118930527-A Amide derivative regulator, preparation method and application thereof 江苏豪森药业集团有限公司 2024-11-12 — — CN disclosed
US-20240239767-A1 PCSK9 INHIBITORS AND METHODS OF USE THEREOF ASTRAZENECA AB (SE) 2024-07-18 — — US disclosed
WO-2024126773-A1 IMIDAZO[4,5-B]PYRIDINE DERIVATIVES AS PCSK9 INHIBITORS AND METHODS OF USE THEREOF ASTRAZENECA AB (SE) 2024-06-20 — — WO disclosed
US-11344637-B2 Probes for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2022-05-31 — — US disclosed
EP-3340796-B1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION INC (US) 2021-04-21 — — EP disclosed
EP-3340796-B1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION INC (US) 2021-04-21 — — EP disclosed
CN-108135172-B Probes for imaging huntingtin CHDI基金会股份有限公司 2021-03-30 — — CN disclosed
US-20210060187-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2021-03-04 — — US disclosed
US-10765764-B2 Probes for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2020-09-08 — — US disclosed
EP-2303894-A1 THIAZOLO [5, 4-B] PYRIDINE AND OXAZOLO [5, 4-B] PYRIDINE DERIVATIVES AS ANTIBACTERIAL AGENTS AstraZeneca AB (SE) 2011-04-06 — — EP disclosed
US-20100305067-A1 ANTIBACTERIAL CONDENSED THIAZOLES BIOTA EUROPE LTD (GB) 2010-12-02 — — US disclosed
US-20100305067-A1 ANTIBACTERIAL CONDENSED THIAZOLES BIOTA EUROPE LTD (GB) 2010-12-02 — — US disclosed
US-20100305067-A1 ANTIBACTERIAL CONDENSED THIAZOLES BIOTA EUROPE LTD (GB) 2010-12-02 — — US disclosed
EP-2231653-A1 ANTIBACTERIAL CONDENSED THIAZOLES Biota Europe Ltd (GB) 2010-09-29 — — EP disclosed
US-20100137303-A1 NEW COMPOUND 255 ASTRAZENECA AB 2010-06-03 — — US disclosed
US-20100137303-A1 NEW COMPOUND 255 ASTRAZENECA AB 2010-06-03 — — US disclosed
US-20100137303-A1 NEW COMPOUND 255 ASTRAZENECA AB 2010-06-03 — — US disclosed
WO-2009147431-A1 THIAZOLO [5, 4-B] PYRIDINE AND OXAZOLO [5, 4-B] PYRIDINE DERIVATIVES AS ANTIBACTERIAL AGENTS ASTRAZENECA AB (SE) 2009-12-10 — — WO disclosed
WO-2009074812-A1 ANTIBACTERIAL CONDENSED THIAZOLES PROLYSIS LTD (GB) 2009-06-18 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11344637-B2 Probes for imaging huntingtin protein HTT, HYPK, HSPBP1 HTT 1/4885KMT2A 3799/4885NSD1 3770/4885
US-20210060187-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN HTT, HYPK, HSPBP1 HTT 1/4885KMT2A 3799/4885NSD1 3770/4885
US-20240239767-A1 PCSK9 INHIBITORS AND METHODS OF USE THEREOF PCSK9, PCSK7, PCSK6 HTT 2309/4885KMT2A 3510/4885NSD1 2505/4885
US-10765764-B2 Probes for imaging huntingtin protein HTT, HYPK, HSPBP1 HTT 1/4885KMT2A 3799/4885NSD1 3770/4885
US-20100137303-A1 NEW COMPOUND 255 MRPS35, MRPL21, CYP51A1 HTT 4626/4885KMT2A 4582/4885NSD1 4427/4885
US-20100305067-A1 ANTIBACTERIAL CONDENSED THIAZOLES NEK6, NEK1, TXK HTT 4445/4885KMT2A 3154/4885NSD1 966/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.