Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PRNP | P04156 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | TNKS | O95271 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | PKM | P14618 | 2/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL511496 | 0.77 | LMNA (0.41) | GAAALDH1A1MAOBHPGDHSD17B10 | |
| SCHEMBL5324357 | 0.77 | ESR1 (0.43) | ALDH1A1MAOBMAPK1HPGDHSD17B10 | |
| SCHEMBL511124 | 0.77 | KDM4E (0.38) | GAAALDH1A1TSHRMAOBHPGD | |
| SCHEMBL769225 | 0.74 | — | — | |
| SCHEMBL314750 | 0.72 | EGFR (0.47) | ALDH1A1MAOBMAPK1HPGDHSD17B10 | |
| SCHEMBL4417646 | 0.71 | — | — | |
| SCHEMBL5535370 | 0.68 | AHR (0.50) | GAAALDH1A1TSHRMAPK1HPGD | |
| SCHEMBL5963207 | 0.67 | ALDH1A1 (0.58) | GAAALDH1A1TSHRMAOBMAPK1 | |
| SCHEMBL9454247 | 0.67 | PTPRS (0.32) | — | |
| SCHEMBL7234572 | 0.67 | ATM (0.38) | CYP2A6ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105209030-A | Compounds for stabilizing ryanodine receptors from aberrant levels of calcium release | UNIV ROSALIND FRANKLIN MEDICINE & SCIENCE | 2015-12-30 | — | — | CN | claimed |
| CN-101990433-A | Compounds that enhance atoh-1 expression | BRIGHAM & WOMENS HOSPITAL | 2011-03-23 | — | — | CN | claimed |
| US-20100016272-A1 | HETEROARYLACRYLAMIDES AND THEIR USE AS PHARMACEUTICALS | SANOFI-AVENTIS (FR) | 2010-01-21 | — | — | US | claimed |
| EP-2099753-A2 | HETEROARYLACRYLAMIDES AND THEIR USE AS PHARMACEUTICALS | Sanofi-Aventis (FR) | 2009-09-16 | — | — | EP | claimed |
| WO-2008074413-A2 | HETEROARYLACRYLAMIDES AND THEIR USE AS PHARMACEUTICALS FOR THE STIMULATION OF THE EXPRESSION OF ENDOTHELIAL NO SYNTHASE | SANOFI-AVENTIS (FR) | 2008-06-26 | — | — | WO | claimed |
| EP-1257265-B1 | USE OF 2-PHENYLENE DIAMINE DERIVATIVES FOR THE TREATMENT OF INFECTIONS | BIOAGENCY AG (DE) | 2004-01-21 | — | — | EP | claimed |
| US-20030036532-A1 | Use of 2-phenylene diamine derivatives for the treatment of infections | JOMAA PHARMAKA GMBH (DE) | 2003-02-20 | — | — | US | claimed |
| EP-1257265-A2 | USE OF 2-PHENYLENE DIAMINE DERIVATIVES FOR THE TREATMENT OF INFECTIONS | Jomaa Pharmaka GmbH (DE) | 2002-11-20 | — | — | EP | claimed |
| WO-2001070026-A2 | 2-PHENYLENEDIAMINE DERIVATIVES AS HERBICIDES | JOMAA PHARMAKA GMBH (DE) | 2001-09-27 | — | — | WO | claimed |
| WO-2001062709-A2 | USE OF 2-PHENYLENE DIAMINE DERIVATIVES FOR THE TREATMENT OF INFECTIONS | JOMAA PHARMAKA GMBH (DE) | 2001-08-30 | — | — | WO | claimed |
| CN-117377478-A | Methods and compositions for regenerating hair cells in the inner ear of an adult mammal | 麻省眼耳科医院 | 2024-01-09 | — | — | CN | disclosed |
| CN-110078659-B | Isopimaric acid heterocyclic acylhydrazone derivative and preparation method and application thereof | 中国林业科学研究院林产化学工业研究所 | 2022-06-07 | — | — | CN | disclosed |
| CN-112359018-A | Methods and compositions for regenerating hair cells and/or supporting cells | 麻省眼耳医院 | 2021-02-12 | — | — | CN | disclosed |
| CN-104869987-B | Methods and compositions for regenerating hair cells and/or supporting cells | 麻省眼耳医院 | 2020-10-16 | — | — | CN | disclosed |
| CN-105209030-B | For stablizing the compound that blue Buddhist nun's alkali receptor makes it from the calcium release of abnormal level | 罗莎琳德富兰克林医科大学 | 2018-06-12 | — | — | CN | disclosed |
| US-20070208022-A1 | HIV INHIBITING 5-CARBO- OR HETEROCYCLYL SUBSTITUTED PYRIMIDINES | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2007-09-06 | — | — | US | disclosed |
| EP-1257265-B1 | USE OF 2-PHENYLENE DIAMINE DERIVATIVES FOR THE TREATMENT OF INFECTIONS | BIOAGENCY AG (DE) | 2004-01-21 | — | — | EP | disclosed |
| US-20030036532-A1 | Use of 2-phenylene diamine derivatives for the treatment of infections | JOMAA PHARMAKA GMBH (DE) | 2003-02-20 | — | — | US | disclosed |
| WO-2001070026-A2 | 2-PHENYLENEDIAMINE DERIVATIVES AS HERBICIDES | JOMAA PHARMAKA GMBH (DE) | 2001-09-27 | — | — | WO | disclosed |
| US-5886185-A | ANTITUMOR AGENTS, ANTICARCINOGENIC AGENTS | DEVELOPMENT CENTER FOR BIOTECHNOLOY (TW) | 1999-03-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030036532-A1 | Use of 2-phenylene diamine derivatives for the treatment of infections | HRH2, ASPH, NQO2 | GAA 1200/4885ALDH1A1 1419/4885TSHR 3054/4885 |
| US-20100016272-A1 | HETEROARYLACRYLAMIDES AND THEIR USE AS PHARMACEUTICALS | NOS3, PTGIS, NOS1 | GAA 1721/4885ALDH1A1 2657/4885TSHR 519/4885 |
| US-20070208022-A1 | HIV INHIBITING 5-CARBO- OR HETEROCYCLYL SUBSTITUTED PYRIMIDINES | CCNO, COX6C, CCR6 | GAA 4754/4885ALDH1A1 3126/4885TSHR 2612/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.