Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 3/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | ITGB2 | P05107 | 3/20 | 0.34 |
| ▸ | ICAM1 | P05362 | 3/20 | 0.34 |
| ▸ | ITGAL | P20701 | 3/20 | 0.34 |
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3618285 | 0.86 | ROCK2 (0.40) | CDC7MAPKAPK2ROCK2MAP4K4CDK2 | |
| SCHEMBL3609410 | 0.84 | CDK9 (0.49) | CDC7MAPKAPK2ROCK2MAP4K4CDK2 | |
| Hydrochloric Acid SCHEMBL3617474 | 0.83 | CDK9 (0.48) | CDC7MAPKAPK2ROCK2MAP4K4CDK2 | |
| SCHEMBL14283758 | 0.83 | CDC7 (0.40) | CDC7MAPKAPK2ROCK2MAP4K4CDK2 | |
| SCHEMBL3618175 | 0.83 | TBK1 (0.45) | ROCK2KDM4EMAPK1TBK1 | |
| SCHEMBL3617304 | 0.81 | KCNMA1 (0.44) | CDC7MAPKAPK2ROCK2MAP4K4CDK2 | |
| SCHEMBL3616822 | 0.78 | NR1H2 (0.47) | RETTBK1 | |
| SCHEMBL3615497 | 0.77 | KCNMA1 (0.48) | CDC7MAPKAPK2ROCK2MAP4K4CDK2 | |
| SCHEMBL3618166 | 0.76 | TBK1 (0.39) | MAPKAPK2TBK1 | |
| SCHEMBL13408151 | 0.76 | NR1H2 (0.44) | RETKMT2ATBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100105664-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2010-04-29 | — | — | US | disclosed |
| US-20100105664-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2010-04-29 | — | — | US | disclosed |
| EP-2069333-A1 | PYRROLE DERIVATIVES USEFUL FOR THE TREATMENT OF CYTOKINE-MEDIATED DISEASES | Novartis Ag (CH) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008034600-A1 | PYRROLE DERIVATIVES USEFUL FOR THE TREATMENT OF CYTOKINE-MEDIATED DISEASES | NOVARTIS AG (CH) | 2008-03-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105664-A1 | ORGANIC COMPOUNDS | SLCO1B3, SLCO1B1, SLC10A6 | CDC7 4089/4885MAPKAPK2 4395/4885ROCK2 3665/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.