Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLG | P00747 | 1/20 | 0.52 |
| ▸ | PLAU | P00749 | 1/20 | 0.52 |
| ▸ | PLAT | P00750 | 1/20 | 0.52 |
| ▸ | KLK1 | P06870 | 1/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.45 |
| ▸ | JAK2 | O60674 | 5/20 | 0.45 |
| ▸ | JAK3 | P52333 | 5/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.45 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.42 |
| ▸ | NISCH | Q9Y2I1 | 5/20 | 0.41 |
| ▸ | MAOA | P21397 | 5/20 | 0.41 |
| ▸ | MAOB | P27338 | 5/20 | 0.41 |
| ▸ | IKBKB | O14920 | 4/20 | 0.40 |
| ▸ | JAK1 | P23458 | 2/20 | 0.40 |
| ▸ | TYK2 | P29597 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 3/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31596756 | 0.90 | CYP3A4 (0.43) | PLGPLAUPLATKLK1ROCK2 | |
| SCHEMBL29941308 | 0.81 | PLG (0.63) | PLGPLAUPLATKLK1MAOA | |
| SCHEMBL21067278 | 0.81 | PLG (0.63) | PLGPLAUPLATKLK1MAOA | |
| SCHEMBL25005546 | 0.76 | PRKCZ (0.37) | ROCK2JAK2JAK3ROCK1IMPDH2 | |
| SCHEMBL8612775 | 0.74 | MAOB (0.53) | NISCHMAOAMAOBCYP3A4HTR2C | |
| SCHEMBL8612773 | 0.74 | MAOB (0.53) | NISCHMAOAMAOBCYP3A4HTR2C | |
| SCHEMBL2300247 | 0.74 | PRKCZ (0.45) | ROCK1IKBKB | |
| SCHEMBL3613021 | 0.72 | ROCK2 (0.76) | ROCK2JAK2JAK3ROCK1IMPDH2 | |
| SCHEMBL25478352 | 0.72 | ROCK2 (0.76) | ROCK2JAK2JAK3ROCK1IMPDH2 | |
| SCHEMBL2163450 | 0.72 | ROCK2 (0.76) | ROCK2JAK2JAK3ROCK1IMPDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100137364-A1 | 6-Aminoisoquinoline Compounds | AERIE PHARMACEUTICALS, INC. (US) | 2010-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137364-A1 | 6-Aminoisoquinoline Compounds | COQ8A, PGC, AGK | PLG 1594/4885PLAU 2651/4885PLAT 3264/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.