Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.72 |
| ▸ | CA1 | P00915 | 2/20 | 0.57 |
| ▸ | CA2 | P00918 | 2/20 | 0.57 |
| ▸ | CA9 | Q16790 | 1/20 | 0.57 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.53 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.48 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.46 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.45 |
| ▸ | HNF4A | P41235 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23003 | 0.87 | TSHR (0.79) | TSHRCA1CA2CA9FOLH1 | |
| SCHEMBL16950095 | 0.86 | TSHR (0.72) | TSHRCA1CA2CA9FOLH1 | |
| Ammonia Solution, Strong SCHEMBL27527756 | 0.85 | TSHR (0.76) | TSHRCA1CA2CA9FOLH1 | |
| SCHEMBL28370887 | 0.85 | TSHR (0.76) | TSHRCA1CA2CA9FOLH1 | |
| SCHEMBL2292722 | 0.84 | TSHR (0.74) | TSHRCA1CA2CA9FOLH1 | |
| SCHEMBL7759867 | 0.84 | TSHR (0.74) | TSHRCA1CA2CA9FOLH1 | |
| SCHEMBL29580520 | 0.84 | TSHR (0.74) | TSHRCA1CA2CA9FOLH1 | |
| SCHEMBL69041 | 0.84 | TSHR (1.00) | TSHRCA1CA2CA9FOLH1 | |
| SCHEMBL6511913 | 0.83 | PTPN1 (0.55) | TSHRCA1CA2CA9FOLH1 | |
| SCHEMBL4872353 | 0.82 | TSHR (0.72) | TSHRCA1CA2CA9FOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100056505-A1 | Substituted Pyrazalones | BIOGEN IDEC MA INC. | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056505-A1 | Substituted Pyrazalones | ACVR1, ACVRL1, TGFBR1 | TSHR 1477/4885CA1 4453/4885CA2 2992/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.