Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 5/20 | 0.55 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.55 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | HNF4A | P41235 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | BCL2 | P10415 | 1/20 | 0.43 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.43 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.42 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MPO | P05164 | 1/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.42 |
| ▸ | DCLRE1A | Q6PJP8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8961442 | 0.88 | PTPN1 (0.65) | PTPN1PTPN2PTPN6TSHRHNF4A | |
| SCHEMBL14303025 | 0.85 | PTPN1 (0.57) | PTPN1PTPN2PTPN6TSHRHNF4A | |
| SCHEMBL11772230 | 0.84 | CES2 (0.41) | PTPN1PTPN2PTPN6TSHRHNF4A | |
| SCHEMBL9440497 | 0.83 | PTPN1 (0.55) | PTPN1PTPN2PTPN6TSHRHNF4A | |
| SCHEMBL7427856 | 0.83 | TP53 (0.47) | PTPN1TSHRALDH1A1KDM4E | |
| SCHEMBL3613148 | 0.83 | TSHR (0.72) | PTPN1PTPN2PTPN6TSHRHNF4A | |
| SCHEMBL3303005 | 0.81 | PTPN1 (0.53) | PTPN1PTPN2PTPN6TSHRHNF4A | |
| SCHEMBL200520 | 0.81 | CYP4F2 (0.44) | TSHRCES2CES1ALDH1A1 | |
| SCHEMBL6772376 | 0.81 | TSHR (0.69) | PTPN1PTPN2PTPN6TSHRHNF4A | |
| SCHEMBL6441850 | 0.80 | PTPN1 (0.62) | PTPN1PTPN2PTPN6TSHRHNF4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050215598-A1 | Phenylalanine derivatives | CELLTECH R&D LTD. (GB) | 2005-09-29 | — | — | US | disclosed |
| EP-1056714-B1 | PHENYLALANINE DERIVATIVES AS INHIBITORS OF ALPHA4 INTEGRINS | CELLTECH THERAPEUTICS LTD (GB) | 2004-08-11 | — | — | EP | disclosed |
| US-20030166691-A1 | Phenylalanine derivatives | ARCHIBALD SARAH CATHERINE (GB) | 2003-09-04 | — | — | US | disclosed |
| US-6555562-B1 | 2-Carboxybenzoyl-(N'-3,5-dichloroisonicotinoyl)-L-4aminophenyl alanine, for example; inhibit the binding of alpha-4 integrins to their ligands, use to treat immune or inflammatory disorders | CELLTECH R&D LIMITED (GB) | 2003-04-29 | — | — | US | disclosed |
| US-6197794-B1 | ANTIINFLAMAMTORY AGENTS; IMMUNOLOGY DISEASES | CELLTECH THERAPEUTICS LIMITED (GB) | 2001-03-06 | — | — | US | disclosed |
| EP-1056714-A1 | PHENYLALANINE DERIVATIVES AS INHIBITORS OF ALPHA4 INTEGRINS | CELLTECH THERAPEUTICS LIMITED (GB) | 2000-12-06 | — | — | EP | disclosed |
| EP-1044215-A1 | ANTI-INFLAMMATORY PHENYLALANINE DERIVATIVES | CELLTECH THERAPEUTICS LIMITED (GB) | 2000-10-18 | — | — | EP | disclosed |
| WO-1999043642-A1 | PHENYLALANINE DERIVATIVES AS INHIBITORS OF ALPHA4 INTEGRINS | CELLTECH THERAPEUTICS LIMITED (GB) | 1999-09-02 | — | — | WO | disclosed |
| WO-1999035163-A1 | PHENYLALANINE DERIVATIVES | CELLTECH THERAPEUTICS LIMITED (GB) | 1999-07-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030166691-A1 | Phenylalanine derivatives | VCAM1, PAH, ITGB4 | PTPN1 492/4885PTPN2 1154/4885PTPN6 878/4885 |
| US-20050215598-A1 | Phenylalanine derivatives | PAH, ITGB4, VCAM1 | PTPN1 502/4885PTPN2 1013/4885PTPN6 676/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.