Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRPF1 | P55201 | 1/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.45 |
| ▸ | CSNK2A1 | P68400 | 5/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 4/20 | 0.44 |
| ▸ | CSNK2B | P67870 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | DNA2 | P51530 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1465916 | 0.86 | CSNK2A2 (0.54) | BRPF1NOTUMCSNK2A1CSNK2A2CSNK2B | |
| SCHEMBL1275907 | 0.86 | ADRA2A (0.50) | BRPF1NOTUMCSNK2A1CSNK2A2CSNK2B | |
| SCHEMBL27447876 | 0.80 | BRPF1 (0.42) | BRPF1CSNK2A1CSNK2A2CSNK2BCYP1A2 | |
| SCHEMBL7515189 | 0.79 | CYP1A2 (0.49) | BRPF1NOTUMCSNK2A1CSNK2A2CSNK2B | |
| SCHEMBL3978031 | 0.76 | BRPF1 (0.77) | BRPF1CSNK2A1CSNK2A2CSNK2BHSD17B10 | |
| SCHEMBL7512239 | 0.74 | DNA2 (0.56) | CSNK2A1CSNK2A2CSNK2BCYP1A2HSD17B10 | |
| SCHEMBL3995494 | 0.74 | GPR84 (0.51) | BRPF1NOTUMCYP1A2HSD17B10NR4A2 | |
| SCHEMBL6451616 | 0.74 | HSD17B10 (0.47) | NOTUMCSNK2A1CSNK2A2CSNK2BCYP1A2 | |
| SCHEMBL14037111 | 0.74 | CSNK2A1 (0.39) | BRPF1NOTUMCSNK2A1CSNK2A2CSNK2B | |
| SCHEMBL24762220 | 0.72 | MAPT (0.39) | BRPF1CYP1A2NR4A2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100035862-A1 | NOVEL AZA-CYCLIC INDOLE-2-CARBOXAMIDES AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2010-02-11 | — | — | US | disclosed |
| WO-2009158375-A1 | AZA-CYLIC INDOLE- 2 -CARBOXAMIDES AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2009-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035862-A1 | NOVEL AZA-CYCLIC INDOLE-2-CARBOXAMIDES AND METHODS OF USE THEREOF | IDO2, IDO1, INMT | BRPF1 2584/4885NOTUM 4285/4885CSNK2A1 409/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.