Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 4/20 | 0.64 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.64 |
| ▸ | EP300 | Q09472 | 1/20 | 0.56 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.56 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.56 |
| ▸ | BRD4 | O60885 | 2/20 | 0.54 |
| ▸ | HTR6 | P50406 | 8/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | SQSTM1 | Q13501 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA4 | P22748 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3623223 | 0.96 | KEAP1 (0.59) | KEAP1NFE2L2EP300KAT2BKAT8 | |
| SCHEMBL1380665 | 0.88 | HTR6 (0.52) | KEAP1NFE2L2EP300HTR6 | |
| SCHEMBL3626154 | 0.88 | HTR6 (0.55) | KEAP1NFE2L2HTR6SQSTM1 | |
| SCHEMBL3623176 | 0.88 | KEAP1 (0.64) | KEAP1NFE2L2BRD4HTR6MEN1 | |
| SCHEMBL3622053 | 0.88 | HKDC1 (0.56) | KEAP1NFE2L2BRD4HTR6KMT2A | |
| SCHEMBL1377079 | 0.87 | KEAP1 (0.67) | KEAP1NFE2L2HTR6SMN1; SMN2SQSTM1 | |
| SCHEMBL3626233 | 0.87 | HTR6 (0.52) | KEAP1NFE2L2BRD4HTR6MEN1 | |
| Hydrochloric Acid SCHEMBL1377991 | 0.87 | HKDC1 (0.55) | KEAP1NFE2L2BRD4HTR6KMT2A | |
| Hydrochloric Acid SCHEMBL1376917 | 0.87 | HTR6 (0.54) | KEAP1NFE2L2HTR6SQSTM1 | |
| Hydrochloric Acid SCHEMBL1379130 | 0.87 | KEAP1 (0.63) | KEAP1NFE2L2BRD4HTR6MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100222330-A1 | New Compounds | BIOVITRUM AB (SE) | 2010-09-02 | — | — | US | disclosed |
| US-7572787-B2 | Substituted naphthalene sulfonamides | BIOVITRUM AB (SE) | 2009-08-11 | — | — | US | disclosed |
| US-20070066598-A1 | Compounds | BIOVITRUM AB, A SWEDEN CORPORATION | 2007-03-22 | — | — | US | disclosed |
| US-20070066599-A1 | New compounds | BIOVITRUM AB, A SWEDEN CORPORATION | 2007-03-22 | — | — | US | disclosed |
| US-20070066600-A1 | Compounds | PROXIMAGEN NEUROSCIENCE PLC (GB) | 2007-03-22 | — | — | US | disclosed |
| US-7144883-B2 | Bicyclic sulfonamide compounds | BIOVITRUM AB (SE) | 2006-12-05 | — | — | US | disclosed |
| EP-1412325-A1 | SUBSTITUTED SULFONAMIDE COMPOUNDS, PROCESS FOR THEIR USE AS MEDICAMENT FOR THE TREATMENT OF CNS DISORDERS, OBESITY AND TYPE II DIABETES | BIOVITRUM AB (SE) | 2004-04-28 | — | — | EP | disclosed |
| US-20030158202-A1 | Substituted fused ring sulfonamides containing, e.g., naphthalene, isoquinoline, quinoline, benzofuran or benzothiophene rings; treatment of conditions relating to obesity, type II diabetes and CNS disorders | PROXIMAGEN NEUROSCIENCE PLC (GB) | 2003-08-21 | — | — | US | disclosed |
| WO-2002100822-A1 | SUBSTITUTED SULFONAMIDE COMPOUNDS, PROCESS FOR THEIR USE AS MEDICAMENT FOR THE TREATMENT OF CNS DISORDERS, OBESITY AND TYPE II DIABETES | BIOVITRUM AB (SE) | 2002-12-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070066599-A1 | New compounds | SULT2A1, GPR119, STS | KEAP1 1645/4885NFE2L2 597/4885EP300 1401/4885 |
| US-20070066598-A1 | Compounds | SULT2A1, STS, SLC5A2 | KEAP1 1144/4885NFE2L2 406/4885EP300 1372/4885 |
| US-20030158202-A1 | Substituted fused ring sulfonamides containing, e.g., naphthalene, isoquinoline, quinoline, benzofuran or benzothiophene rings; treatment of conditions relating to obesity, type II diabetes and CNS disorders | SULT2A1, SULT1A1, SULT1E1 | KEAP1 309/4885NFE2L2 24/4885EP300 1437/4885 |
| US-20070066600-A1 | Compounds | SULT2A1, STS, SLC5A2 | KEAP1 1144/4885NFE2L2 406/4885EP300 1372/4885 |
| US-20100222330-A1 | New Compounds | SULT2A1, GPR119, STS | KEAP1 1645/4885NFE2L2 597/4885EP300 1401/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.