Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8254154 | 0.87 | MAPT (0.39) | CYP3A4LMNATP53HPGDALOX15 | |
| SCHEMBL16302410 | 0.82 | POLB (0.40) | CYP3A4LMNATP53HPGDALOX15 | |
| SCHEMBL198146 | 0.80 | GABRA1 (0.42) | CYP3A4LMNAHPGDALOX15CA1 | |
| SCHEMBL15180048 | 0.80 | CA1 (0.53) | CYP3A4LMNATP53HPGDALOX15 | |
| SCHEMBL10019863 | 0.78 | CYP3A4 (0.42) | CYP3A4LMNATP53HPGDALOX15 | |
| SCHEMBL852265 | 0.76 | CA2 (0.53) | CYP3A4LMNATP53HPGDALOX15 | |
| SCHEMBL18892668 | 0.76 | LMNA (0.41) | CYP3A4LMNATP53HPGDALOX15 | |
| SCHEMBL21519791 | 0.75 | MAPT (0.36) | CYP3A4LMNATP53HPGDALOX15 | |
| SCHEMBL17594925 | 0.74 | POLB (0.44) | CYP3A4TP53ALOX15CA1CA2 | |
| SCHEMBL3770921 | 0.72 | CA2 (0.42) | CYP3A4LMNATP53HPGDALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111848683-A | Biphenyl tridentate phosphite ligand and preparation method and application thereof | 南方科技大学 | 2020-10-30 | — | — | CN | disclosed |
| CN-111747827-A | Biphenyl triphenol compound and preparation method and application thereof | 南方科技大学 | 2020-10-09 | — | — | CN | disclosed |
| US-7834062-B2 | Aminoalkylphenols, methods of using and making the same | MERCK SHARP & DOHME CORP. (US) | 2010-11-16 | — | — | US | disclosed |
| US-20090298949-A1 | AMINOALKYLPHENOLS, METHODS OF USING AND MAKING THE SAME | MERCK SHARP & DOHME LLC | 2009-12-03 | — | — | US | disclosed |
| US-7589127-B2 | Aminoalkylphenols, methods of using and making the same | MERCK & CO., INC. (US) | 2009-09-15 | — | — | US | disclosed |
| EP-1517879-A4 | AMINOALKYLPHENOLS, METHODS OF USING AND MAKING THE SAME | MERCK & CO INC (US) | 2006-09-13 | — | — | EP | disclosed |
| US-20050234265-A1 | Aminoalkylphenols, methods of using and making the same | MERCK SHARP & DOHME LLC | 2005-10-20 | — | — | US | disclosed |
| EP-1517879-A1 | AMINOALKYLPHENOLS, METHODS OF USING AND MAKING THE SAME | Merck & Co., Inc. (US) | 2005-03-30 | — | — | EP | disclosed |
| WO-2004000783-A1 | AMINOALKYLPHENOLS, METHODS OF USING AND MAKING THE SAME | MERCK & CO., INC. (US) | 2003-12-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090298949-A1 | AMINOALKYLPHENOLS, METHODS OF USING AND MAKING THE SAME | NPEPPS, PHOSPHO1, LNPEP | CYP3A4 874/4885LMNA 1464/4885TP53 3650/4885 |
| US-20050234265-A1 | Aminoalkylphenols, methods of using and making the same | NPEPPS, PHOSPHO1, LNPEP | CYP3A4 874/4885LMNA 1464/4885TP53 3650/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.