Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3621681 | 0.82 | MPO (0.48) | MEN1KMT2AALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL3621893 | 0.80 | ALDH1A1 (0.42) | MEN1KMT2AALDH1A1KDM4ELMNA | |
| SCHEMBL14492164 | 0.79 | ALDH1A1 (0.50) | MEN1KMT2AALDH1A1NPSR1CYP1A2 | |
| SCHEMBL3622905 | 0.78 | ALDH1A1 (0.43) | MEN1KMT2AALDH1A1GAAKDM4E | |
| SCHEMBL3620361 | 0.77 | MPO (0.50) | MEN1KMT2APOLBGAAHRH3 | |
| SCHEMBL3615064 | 0.77 | MPO (0.48) | MEN1KMT2AALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL3619585 | 0.76 | NR5A2 (0.42) | KMT2AALDH1A1CYP1A2CYP2C19CYP2D6 | |
| SCHEMBL3621214 | 0.76 | GSR (0.54) | KMT2AALDH1A1CYP1A2CYP2C19ALOX15 | |
| SCHEMBL13778175 | 0.75 | ALDH1A1 (0.56) | MEN1KMT2AALDH1A1NPSR1CYP1A2 | |
| SCHEMBL3707152 | 0.75 | VNN1 (0.33) | SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1517879-A4 | AMINOALKYLPHENOLS, METHODS OF USING AND MAKING THE SAME | MERCK & CO INC (US) | 2006-09-13 | — | — | EP | claimed |
| US-20050234265-A1 | Aminoalkylphenols, methods of using and making the same | MERCK SHARP & DOHME LLC | 2005-10-20 | — | — | US | claimed |
| EP-1517879-A1 | AMINOALKYLPHENOLS, METHODS OF USING AND MAKING THE SAME | Merck & Co., Inc. (US) | 2005-03-30 | — | — | EP | claimed |
| WO-2004000783-A1 | AMINOALKYLPHENOLS, METHODS OF USING AND MAKING THE SAME | MERCK & CO., INC. (US) | 2003-12-31 | — | — | WO | claimed |
| US-7834062-B2 | Aminoalkylphenols, methods of using and making the same | MERCK SHARP & DOHME CORP. (US) | 2010-11-16 | — | — | US | disclosed |
| US-20090298949-A1 | AMINOALKYLPHENOLS, METHODS OF USING AND MAKING THE SAME | MERCK SHARP & DOHME LLC | 2009-12-03 | — | — | US | disclosed |
| US-7589127-B2 | Aminoalkylphenols, methods of using and making the same | MERCK & CO., INC. (US) | 2009-09-15 | — | — | US | disclosed |
| EP-1517879-A4 | AMINOALKYLPHENOLS, METHODS OF USING AND MAKING THE SAME | MERCK & CO INC (US) | 2006-09-13 | — | — | EP | disclosed |
| US-20050234265-A1 | Aminoalkylphenols, methods of using and making the same | MERCK SHARP & DOHME LLC | 2005-10-20 | — | — | US | disclosed |
| EP-1517879-A1 | AMINOALKYLPHENOLS, METHODS OF USING AND MAKING THE SAME | Merck & Co., Inc. (US) | 2005-03-30 | — | — | EP | disclosed |
| WO-2004000783-A1 | AMINOALKYLPHENOLS, METHODS OF USING AND MAKING THE SAME | MERCK & CO., INC. (US) | 2003-12-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090298949-A1 | AMINOALKYLPHENOLS, METHODS OF USING AND MAKING THE SAME | NPEPPS, PHOSPHO1, LNPEP | MEN1 2773/4885KMT2A 261/4885ALDH1A1 1120/4885 |
| US-20050234265-A1 | Aminoalkylphenols, methods of using and making the same | NPEPPS, PHOSPHO1, LNPEP | MEN1 2773/4885KMT2A 261/4885ALDH1A1 1120/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.