Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.33 |
| ▸ | BRD4 | O60885 | 3/20 | 0.33 |
| ▸ | HAT1 | O14929 | 2/20 | 0.31 |
| ▸ | EP300 | Q09472 | 2/20 | 0.31 |
| ▸ | RORC | P51449 | 2/20 | 0.31 |
| ▸ | F10 | P00742 | 1/20 | 0.31 |
| ▸ | F9 | P00740 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.30 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.30 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL361665 | 0.93 | HPGD (0.37) | METGPBAR1BRD4F10 | |
| SCHEMBL364618 | 0.93 | MET (0.42) | METGPBAR1BRD4RORCF10 | |
| SCHEMBL362599 | 0.91 | BRD4 (0.40) | METGPBAR1BRD4EP300RORC | |
| SCHEMBL363606 | 0.91 | GPBAR1 (0.35) | METGPBAR1BRD4F10 | |
| SCHEMBL364487 | 0.86 | BRD4 (0.42) | GPBAR1BRD4F9NTRK1 | |
| SCHEMBL364524 | 0.85 | PTGS2 (0.36) | GPBAR1BRD4HAT1EP300F9 | |
| SCHEMBL363071 | 0.84 | BRD4 (0.37) | GPBAR1BRD4F9 | |
| SCHEMBL1389655 | 0.83 | F9 (0.34) | GPBAR1BRD4RORCF10F9 | |
| SCHEMBL369186 | 0.83 | F9 (0.34) | GPBAR1BRD4RORCF10F9 | |
| SCHEMBL1389659 | 0.83 | F9 (0.34) | GPBAR1BRD4RORCF10F9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | claimed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | claimed |
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |