Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL361665 | 0.97 | HPGD (0.37) | GPBAR1HPGDMETBRD4MAPK14 | |
| SCHEMBL362599 | 0.95 | BRD4 (0.40) | GPBAR1HPGDMETBRD4MAPK14 | |
| SCHEMBL364618 | 0.92 | MET (0.42) | GPBAR1HPGDMETBRD4F10 | |
| SCHEMBL364415 | 0.91 | HPGD (0.37) | HPGDMETBRD4MAPK14F10 | |
| SCHEMBL362147 | 0.91 | MET (0.34) | GPBAR1METBRD4F10 | |
| SCHEMBL363829 | 0.86 | BRD4 (0.41) | HPGDMETBRD4MAPK14F10 | |
| SCHEMBL364487 | 0.86 | BRD4 (0.42) | GPBAR1BRD4 | |
| SCHEMBL363154 | 0.85 | HPGD (0.35) | HPGDMETBRD4MAPK14F10 | |
| SCHEMBL364524 | 0.85 | PTGS2 (0.36) | GPBAR1HPGDBRD4MAPK14POLB | |
| SCHEMBL363071 | 0.84 | BRD4 (0.37) | GPBAR1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | claimed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | claimed |
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |