Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.33 |
| ▸ | F9 | P00740 | 4/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.30 |
| ▸ | CTSA | P10619 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL364487 | 0.92 | BRD4 (0.42) | BRD4HSD17B2GPBAR1F9S1PR1 | |
| SCHEMBL364524 | 0.89 | PTGS2 (0.36) | BRD4GPBAR1F9CTSA | |
| SCHEMBL361665 | 0.86 | HPGD (0.37) | BRD4GPBAR1 | |
| SCHEMBL362599 | 0.84 | BRD4 (0.40) | BRD4GPBAR1 | |
| SCHEMBL362147 | 0.84 | MET (0.34) | BRD4GPBAR1F9 | |
| SCHEMBL363606 | 0.84 | GPBAR1 (0.35) | BRD4GPBAR1 | |
| SCHEMBL364618 | 0.83 | MET (0.42) | BRD4GPBAR1P2RX7 | |
| SCHEMBL1389788 | 0.82 | OPRD1 (0.37) | BRD4OPRD1HSD17B2GPBAR1F9 | |
| SCHEMBL1389780 | 0.82 | OPRD1 (0.37) | BRD4OPRD1HSD17B2GPBAR1F9 | |
| SCHEMBL1389785 | 0.82 | OPRD1 (0.37) | BRD4OPRD1HSD17B2GPBAR1F9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | claimed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | claimed |
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |