Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | MAP3K12 | Q12852 | 2/20 | 0.31 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.30 |
| ▸ | MMP3 | P08254 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL364963 | 0.90 | GPBAR1 (0.32) | PROKR1TLR8TLR7GPBAR1 | |
| SCHEMBL363509 | 0.87 | PROKR1 (0.40) | PROKR1TLR8TLR7MAP3K12 | |
| SCHEMBL364745 | 0.83 | MAPK1 (0.34) | PROKR1TLR8TLR7 | |
| SCHEMBL362899 | 0.81 | TLR8 (0.40) | PROKR1TLR8TLR7MAP3K12GPBAR1 | |
| SCHEMBL363020 | 0.81 | ATR (0.35) | — | |
| SCHEMBL368721 | 0.80 | WNT3A (0.44) | MMP3 | |
| SCHEMBL363070 | 0.79 | ALDH1A1 (0.41) | PROKR1TLR8TLR7 | |
| SCHEMBL363061 | 0.79 | KCNN4 (0.34) | GPBAR1 | |
| SCHEMBL362081 | 0.78 | HSD17B1 (0.33) | — | |
| SCHEMBL363549 | 0.77 | NPC1 (0.34) | TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |