Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | SYK | P43405 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.48 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.48 |
| ▸ | BCL2 | P10415 | 1/20 | 0.46 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3624720 | 0.87 | TSHR (0.48) | NPC1RAB9ASYKGAAMAPT | |
| SCHEMBL3618598 | 0.82 | SGMS2 (0.46) | NPC1RAB9AGAAMAPTSLC5A1 | |
| SCHEMBL23992377 | 0.81 | PTGES (0.50) | TAAR1NPC1RAB9ASYKGAA | |
| SCHEMBL3619586 | 0.79 | LMNA (0.51) | GAAMAPTSLC5A1SLC5A2L3MBTL1 | |
| SCHEMBL21332776 | 0.77 | PLAAT3 (0.55) | TAAR1NPC1RAB9AGAAMAPT | |
| SCHEMBL21332568 | 0.72 | MAPT (0.64) | TAAR1NPC1RAB9ASYKGAA | |
| SCHEMBL29057706 | 0.69 | PTPN1 (0.63) | GAAMAPTSLC5A1SLC5A2BCL2L1 | |
| SCHEMBL9218086 | 0.69 | SLC5A1 (0.61) | NPC1RAB9AGAAMAPTSLC5A1 | |
| SCHEMBL17117361 | 0.69 | ESR1 (0.56) | TAAR1MAPTSMN1; SMN2HDAC2HDAC8 | |
| SCHEMBL21332480 | 0.69 | ESRRG (0.53) | NPC1RAB9AGAAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781485-B2 | Hsp90 family protein inhibitors | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2010-08-24 | — | — | US | disclosed |
| US-20070265268-A1 | Hsp90 Family protein Inhibitors | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-11-15 | — | — | US | disclosed |
| EP-1813270-A1 | HSP90 FAMILY PROTEIN INHIBITORS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-08-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070265268-A1 | Hsp90 Family protein Inhibitors | HSPA4L, HSP90AB1, HSP90B1 | TAAR1 3441/4885NPC1 1764/4885RAB9A 2369/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.