Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMBS | P08397 | 1/20 | 0.40 |
| ▸ | SPR | P35270 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7710879 | 0.76 | — | — | |
| SCHEMBL6601905 | 0.75 | HMBS (0.50) | HMBSSPRKDM4EUSP2HPGD | |
| SCHEMBL9337759 | 0.75 | HMBS (0.50) | HMBSSPRKDM4EUSP2HPGD | |
| SCHEMBL9585659 | 0.70 | HMBS (0.43) | HMBSSPRKDM4EUSP2HPGD | |
| SCHEMBL18900582 | 0.68 | HMBS (0.42) | HMBSSPRKDM4EUSP2HPGD | |
| SCHEMBL17624955 | 0.68 | ALOX15 (0.42) | HMBSHPGD | |
| SCHEMBL7712979 | 0.67 | GSK3B (0.45) | HMBSSPRKDM4EUSP2HPGD | |
| SCHEMBL16163601 | 0.66 | ALDH1A1 (0.41) | HPGD | |
| SCHEMBL14301059 | 0.65 | ALDH1A1 (0.50) | SPRHPGD | |
| SCHEMBL6420225 | 0.65 | ALDH1A1 (0.58) | KDM4EUSP2HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100286181-A1 | PYRROLE DERIVATIVES WITH ANTIBACTERIAL ACTIVITY | ASTRAZENECA AB (SE) | 2010-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286181-A1 | PYRROLE DERIVATIVES WITH ANTIBACTERIAL ACTIVITY | PGLS, UROD, GMPS | HMBS 36/4885SPR 2525/4885KDM4E 1629/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.