Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 9/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | NAAA | Q02083 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8069532 | 0.93 | NAAA (0.45) | EPHX1ACHEALDH1A1GAAMAPK1 | |
| SCHEMBL4629907 | 0.89 | GNAI3 (0.52) | EPHX1ACHEALDH1A1GAAMAPK1 | |
| SCHEMBL14335892 | 0.81 | TRPM8 (0.50) | ALDH1A1GAAMAPK1 | |
| SCHEMBL590532 | 0.80 | EPHX1 (0.59) | EPHX1ACHEALDH1A1ATM | |
| SCHEMBL25326797 | 0.78 | GAA (0.49) | EPHX1ACHEALDH1A1GAAMAPK1 | |
| SCHEMBL9197261 | 0.77 | EPHX1 (0.55) | EPHX1ACHEALDH1A1ATM | |
| SCHEMBL5497744 | 0.76 | EPHX1 (0.43) | EPHX1ACHEALDH1A1GAAMAPK1 | |
| SCHEMBL552606 | 0.75 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2ATMNAAA | |
| SCHEMBL9395279 | 0.75 | EPHX1 (0.53) | EPHX1ACHEALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL7447192 | 0.75 | EPHX1 (0.53) | EPHX1ACHEALDH1A1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2217237-A1 | ARYL-SUBSTITUTED BRIDGED OR FUSED DIAMINES AS MODULATORS OF LEUKOTRIENE A4 HYDROLASE | Janssen Pharmaceutica N.V. (BE) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009058347-A1 | ARYL-SUBSTITUTED BRIDGED OR FUSED DIAMINES AS MODULATORS OF LEUKOTRIENE A4 HYDROLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-05-07 | — | — | WO | disclosed |