Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 5/20 | 0.56 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.56 |
| ▸ | HTR3B | O95264 | 4/20 | 0.56 |
| ▸ | HTR3A | P46098 | 4/20 | 0.56 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.56 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.56 |
| ▸ | PLD1 | Q13393 | 2/20 | 0.49 |
| ▸ | HTR1A | P08908 | 4/20 | 0.46 |
| ▸ | HTR7 | P34969 | 4/20 | 0.46 |
| ▸ | HTR6 | P50406 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HTR2C | P28335 | 3/20 | 0.45 |
| ▸ | USP2 | O75604 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18865595 | 0.81 | HRH4 (0.47) | ALDH1A1KDM4ETP53 | |
| SCHEMBL31466536 | 0.80 | ADRB1 (0.50) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL28990876 | 0.75 | PLD1 (0.41) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL29691124 | 0.75 | HTR2C (0.47) | ADRB1PLD1HTR2CHSD17B10CYP1A2 | |
| Phenylpiperazine SCHEMBL55125 | 0.73 | ADRB1 (1.00) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| Phenylpiperazine SCHEMBL27858598 | 0.73 | ADRB1 (1.00) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| Phenylpiperazine SCHEMBL24889 | 0.73 | ADRB1 (1.00) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| Phenylpiperazine SCHEMBL29135595 | 0.73 | ADRB1 (1.00) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL18592895 | 0.73 | SIGMAR1 (0.51) | ADRB1HTR3EHTR3BHTR3AHTR3D | |
| Phenylpiperazine SCHEMBL15327472 | 0.72 | ADRB1 (0.95) | ADRB1HTR3EHTR3BHTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9260441-B2 | Heteroaryl compounds with cyclic bridging unit | INTERVET INC. (US) | 2016-02-16 | — | — | US | disclosed |
| US-20150080365-A1 | HETEROARYL COMPOUNDS WITH CYCLIC BRIDGING UNIT | INTERVET INC. | 2015-03-19 | — | — | US | disclosed |
| EP-2830615-A1 | HETEROARYL COMPOUNDS WITH CYCLIC BRIDGING UNIT FOR USE IN THE TREATMENT HELMINTH INFECTION | Intervet International B.V. (NL) | 2015-02-04 | — | — | EP | disclosed |
| WO-2013144180-A1 | HETEROARYL COMPOUNDS WITH CYCLIC BRIDGING UNIT FOR USE IN THE TREATMENT HELMINTH INFECTION | INTERVET INTERNATIONAL B.V. (NL) | 2013-10-03 | — | — | WO | disclosed |
| CN-101175729-B | 1-phenyl-3-piperazine-pyrazoles and pesticidal compositions of matter thereof | MERIAL LTD | 2011-06-01 | — | — | CN | disclosed |
| CN-101175729-B | 1-phenyl-3-piperazine-pyrazoles and pesticidal compositions of matter thereof | MERIAL LTD | 2011-06-01 | — | — | CN | disclosed |
| US-7678797-B2 | 1-phenyl-3-piperazine-pyrazoles and pesticidal compositions of matter thereof | MERIAL LIMITED (US) | 2010-03-16 | — | — | US | disclosed |
| US-7678797-B2 | 1-phenyl-3-piperazine-pyrazoles and pesticidal compositions of matter thereof | MERIAL LIMITED (US) | 2010-03-16 | — | — | US | disclosed |
| US-20080113998-A1 | 1-PHENYL-3-PIPERAZINE-PYRAZOLES AND PESTICIDAL COMPOSITIONS OF MATTER THEREOF | MERIAL, INC. | 2008-05-15 | — | — | US | disclosed |
| CN-101175729-A | 1-phenyl-3-piperazine-pyrazoles and pesticidal compositions of matter thereof | MERIAL LTD (US) | 2008-05-07 | — | — | CN | disclosed |
| CN-101175729-A | 1-phenyl-3-piperazine-pyrazoles and pesticidal compositions of matter thereof | MERIAL LTD (US) | 2008-05-07 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080113998-A1 | 1-PHENYL-3-PIPERAZINE-PYRAZOLES AND PESTICIDAL COMPOSITIONS OF MATTER THEREOF | DDT, CYP4Z1, CYP51A1 | ADRB1 1557/4885HTR3E 1764/4885HTR3B 1809/4885 |
| US-20150080365-A1 | HETEROARYL COMPOUNDS WITH CYCLIC BRIDGING UNIT | PIGS, MTCL3, GJB2 | ADRB1 3082/4885HTR3E 2715/4885HTR3B 3098/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.