Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | KCNMA1 | Q12791 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TTR | P02766 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30100412 | 0.93 | MRGPRX4 (0.64) | MRGPRX4LMNAALDH1A1HPGDMAPK1 | |
| SCHEMBL257135 | 0.93 | LMNA (0.61) | LMNAALDH1A1HPGDTDP1KCNMA1 | |
| SCHEMBL48961 | 0.93 | MRGPRX4 (0.64) | MRGPRX4LMNAALDH1A1HPGDMAPK1 | |
| Hydrochloric Acid SCHEMBL7210817 | 0.91 | MRGPRX4 (0.62) | MRGPRX4LMNAALDH1A1HPGDMAPK1 | |
| SCHEMBL30323649 | 0.81 | TSHR (0.53) | MRGPRX4LMNAALDH1A1HPGDMAPK1 | |
| SCHEMBL11306685 | 0.80 | LMNA (0.63) | LMNAALDH1A1HPGDKCNMA1TSHR | |
| SCHEMBL11405282 | 0.80 | HTT (0.69) | MRGPRX4ALDH1A1HPGDMAPK1TDP1 | |
| SCHEMBL6542484 | 0.79 | LMNA (0.61) | LMNAALDH1A1HPGDKCNMA1TSHR | |
| SCHEMBL364764 | 0.79 | ALDH1A1 (0.65) | LMNAALDH1A1HPGDKCNMA1TSHR | |
| SCHEMBL1423874 | 0.79 | FLT1 (0.55) | LMNAALDH1A1KCNMA1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2146973-A2 | NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS | Abbott Laboratories (US) | 2010-01-27 | — | — | EP | disclosed |
| WO-2008130953-A2 | 2-IMIN0IS0THIAZ0LE DERIVATIVES AS CANNABINOID RECEPTOR LIGANDS | ABBOTT LABORATORIES (US) | 2008-10-30 | — | — | WO | disclosed |