Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.45 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.45 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23032664 | 0.84 | MEN1 (0.56) | MEN1KMT2AOPRM1SIGMAR1OPRD1 | |
| SCHEMBL13503839 | 0.82 | MEN1 (0.46) | MEN1KMT2AOPRM1SIGMAR1OPRD1 | |
| SCHEMBL15716013 | 0.79 | OPRM1 (0.44) | MEN1KMT2AOPRM1SIGMAR1OPRD1 | |
| SCHEMBL2896994 | 0.78 | L3MBTL3 (0.46) | OPRM1SIGMAR1OPRD1CHRM3OPRK1 | |
| SCHEMBL14409751 | 0.78 | MEN1 (0.46) | MEN1KMT2AOPRM1SIGMAR1OPRD1 | |
| SCHEMBL13503591 | 0.78 | MEN1 (0.43) | MEN1KMT2AOPRM1SIGMAR1OPRD1 | |
| SCHEMBL6656572 | 0.77 | OPRM1 (0.45) | OPRM1SIGMAR1OPRD1CHRM3OPRK1 | |
| SCHEMBL18770884 | 0.77 | MITF (0.71) | MEN1KMT2AOPRM1SIGMAR1OPRD1 | |
| SCHEMBL3671617 | 0.76 | OPRD1 (0.43) | MEN1KMT2AOPRM1SIGMAR1OPRD1 | |
| SCHEMBL3671615 | 0.76 | OPRD1 (0.43) | MEN1KMT2AOPRM1SIGMAR1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155676-A2 | COMPOUNDS WITH ANTIPARASITIC ACTIVITY, APPLICATIONS THEREOF TO THE TREATMENT OF INFECTIOUS DISEASES CAUSED BY APICOMPLEXANS | Commissariat à l'Energie Atomique (FR) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008146172-A2 | COMPOUNDS WITH ANTIPARASITIC ACTIVITY, APPLICATIONS THEREOF TO THE TREATMENT OF INFECTIOUS DISEASES CAUSED BY APICOMPLEXANS | COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) | 2008-12-04 | — | — | WO | disclosed |