Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 6/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 8/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.43 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7247490 | 0.85 | MEN1 (0.61) | — | |
| SCHEMBL6630919 | 0.78 | LMNA (0.47) | SIGMAR1LMNAL3MBTL1HRH1SLC6A3 | |
| SCHEMBL3630848 | 0.77 | MEN1 (0.48) | OPRM1SIGMAR1OPRD1CHRM3OPRK1 | |
| SCHEMBL2896994 | 0.76 | L3MBTL3 (0.46) | OPRM1SIGMAR1OPRD1CHRM3OPRK1 | |
| SCHEMBL18770884 | 0.74 | MITF (0.71) | OPRM1SIGMAR1OPRD1LMNACHRM3 | |
| SCHEMBL13801291 | 0.72 | OPRM1 (0.45) | OPRM1SIGMAR1OPRD1CHRM3OPRK1 | |
| SCHEMBL6630325 | 0.72 | MEN1 (0.63) | — | |
| SCHEMBL18792902 | 0.70 | OPRM1 (0.65) | OPRM1SIGMAR1OPRD1CHRM3OPRK1 | |
| SCHEMBL5992931 | 0.70 | ALDH1A1 (0.56) | OPRM1SIGMAR1LMNAL3MBTL1OPRL1 | |
| SCHEMBL5992920 | 0.70 | ALDH1A1 (0.56) | OPRM1SIGMAR1LMNAL3MBTL1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1417202-A2 | AMINOPIPERIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2004-05-12 | — | — | EP | disclosed |
| WO-2002079186-A2 | AMINOPIPERIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2002-10-10 | — | — | WO | disclosed |