SCHEMBL3634459

SCHEMBL3634459

Cc1ccc(NC(=O)N2Cc3cccc(C)c3C2)c(C)c1

nearest known ligand 0.67

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 6/20 0.67
NPC1 O15118 4/20 0.67
TAS1R3 Q7RTX0 5/20 0.56
TAS1R1 Q7RTX1 5/20 0.56
TAS1R2 Q8TE23 5/20 0.56
SMN1; SMN2 Q16637 1/20 0.52
NAMPT P43490 1/20 0.51
GRIN2B Q13224 4/20 0.51
PANK3 Q9H999 1/20 0.51
TRPV1 Q8NER1 1/20 0.51
MEN1 O00255 1/20 0.50
KMT2A Q03164 1/20 0.50
THRB P10828 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14817127 0.89 RAB9A (0.82) RAB9ANPC1TAS1R3TAS1R1TAS1R2
SCHEMBL5923951 0.87 TAS1R3 (0.61) RAB9ANPC1TAS1R3TAS1R1TAS1R2
SCHEMBL21476810 0.79 SMN1; SMN2 (0.55) RAB9ANPC1TAS1R3TAS1R1TAS1R2
SCHEMBL5319230 0.78 TAS1R3 (0.52) RAB9ANPC1TAS1R3TAS1R1TAS1R2
SCHEMBL5923924 0.77 TAS1R3 (0.55) RAB9ANPC1TAS1R3TAS1R1TAS1R2
SCHEMBL15029231 0.77 TRAP1 (0.49) RAB9ANPC1TAS1R3TAS1R1TAS1R2
SCHEMBL25683723 0.76 RAB9A (0.97) RAB9ANPC1GRIN2BPANK3MEN1
SCHEMBL19860011 0.76 TAS1R3 (0.75) RAB9ANPC1TAS1R3TAS1R1TAS1R2
SCHEMBL27103000 0.76 TAS1R3 (0.75) RAB9ANPC1TAS1R3TAS1R1TAS1R2
SCHEMBL27102975 0.76 TAS1R3 (0.75) RAB9ANPC1TAS1R3TAS1R1TAS1R2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8709521-B2 Sweetener compositions having enhanced sweetness and improved temporal and/or flavor profiles THE COCA-COLA COMPANY (US) 2014-04-29 US claimed
EP-2160103-A1 SWEETENER COMPOSITIONS HAVING ENHANCED SWEETNESS AND IMPROVED TEMPORAL AND/OR FLAVOR PROFILES THE COCA-COLA COMPANY (US) 2010-03-10 EP claimed
US-20090053378-A1 Sweetener Compositions Having Enhanced Sweetness and Improved Temporal and/or Flavor Profiles THE COCA-COLA COMPANY (US) 2009-02-26 US claimed
WO-2008147726-A1 SWEETENER COMPOSITIONS HAVING ENHANCED SWEETNESS AND IMPROVED TEMPORAL AND/OR FLAVOR PROFILES THE COCA-COLA COMPANY (US) 2008-12-04 WO claimed
EP-2160103-B1 SWEETENER COMPOSITIONS HAVING ENHANCED SWEETNESS AND IMPROVED TEMPORAL AND/OR FLAVOR PROFILES COCA COLA CO (US) 2015-07-29 EP disclosed
EP-2160103-B1 SWEETENER COMPOSITIONS HAVING ENHANCED SWEETNESS AND IMPROVED TEMPORAL AND/OR FLAVOR PROFILES COCA COLA CO (US) 2015-07-29 EP disclosed
US-8709521-B2 Sweetener compositions having enhanced sweetness and improved temporal and/or flavor profiles THE COCA-COLA COMPANY (US) 2014-04-29 US disclosed
US-8709521-B2 Sweetener compositions having enhanced sweetness and improved temporal and/or flavor profiles THE COCA-COLA COMPANY (US) 2014-04-29 US disclosed
US-8709521-B2 Sweetener compositions having enhanced sweetness and improved temporal and/or flavor profiles THE COCA-COLA COMPANY (US) 2014-04-29 US disclosed
EP-2160103-A1 SWEETENER COMPOSITIONS HAVING ENHANCED SWEETNESS AND IMPROVED TEMPORAL AND/OR FLAVOR PROFILES THE COCA-COLA COMPANY (US) 2010-03-10 EP disclosed
US-20090053378-A1 Sweetener Compositions Having Enhanced Sweetness and Improved Temporal and/or Flavor Profiles THE COCA-COLA COMPANY (US) 2009-02-26 US disclosed
US-20090053378-A1 Sweetener Compositions Having Enhanced Sweetness and Improved Temporal and/or Flavor Profiles THE COCA-COLA COMPANY (US) 2009-02-26 US disclosed
US-20090053378-A1 Sweetener Compositions Having Enhanced Sweetness and Improved Temporal and/or Flavor Profiles THE COCA-COLA COMPANY (US) 2009-02-26 US disclosed
WO-2008147726-A1 SWEETENER COMPOSITIONS HAVING ENHANCED SWEETNESS AND IMPROVED TEMPORAL AND/OR FLAVOR PROFILES THE COCA-COLA COMPANY (US) 2008-12-04 WO disclosed