Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.55 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.54 |
| ▸ | CFTR | P13569 | 2/20 | 0.52 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3635139 | 0.91 | ALOX5 (0.69) | ALOX5IMPDH2MAPTPTGS2MEN1 | |
| SCHEMBL3641518 | 0.90 | PTGS2 (0.56) | ALOX5CYP1A1CYP1A2CYP1B1IMPDH2 | |
| SCHEMBL3640612 | 0.88 | AMY1A (0.54) | ALOX5CYP1A1CYP1A2CYP1B1IMPDH2 | |
| SCHEMBL3632755 | 0.88 | ALOX5 (0.53) | ALOX5CYP1A1CYP1A2CYP1B1IMPDH2 | |
| SCHEMBL1041244 | 0.86 | CYP1A1 (0.53) | ALOX5CYP1A1CYP1A2CYP1B1IMPDH2 | |
| SCHEMBL3637159 | 0.86 | PTGS2 (0.60) | ALOX5CYP1A1CYP1A2CYP1B1IMPDH2 | |
| SCHEMBL3637805 | 0.85 | VCP (0.59) | ALOX5CYP1A1CYP1A2CYP1B1IMPDH2 | |
| SCHEMBL3640999 | 0.82 | CYP1B1 (0.53) | ALOX5CYP1A1CYP1A2CYP1B1IMPDH2 | |
| SCHEMBL3637592 | 0.81 | CSNK2A1 (0.53) | ALOX5MAPTPTGS2MEN1KMT2A | |
| SCHEMBL3633219 | 0.80 | PSEN1 (0.64) | ALOX5CYP1A1CYP1A2CYP1B1IMPDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155740-A1 | HETARYLANILINES AS MODULATORS FOR AMYLOID BETA | F. Hoffmann-Roche AG (CH) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008138753-A1 | HETARYLANILINES AS MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2008-11-20 | — | — | WO | disclosed |