Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.53 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.51 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.51 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.51 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.51 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.51 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.48 |
| ▸ | MEN1 | O00255 | 7/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3633219 | 0.90 | PSEN1 (0.64) | CSNK2A1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3637159 | 0.89 | PTGS2 (0.60) | CSNK2A1KMT2AMEN1NPC1MAPT | |
| SCHEMBL3637805 | 0.88 | VCP (0.59) | CSNK2A1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3641518 | 0.88 | PTGS2 (0.56) | CSNK2A1CYP3A4KMT2AMEN1NPC1 | |
| SCHEMBL3632755 | 0.84 | ALOX5 (0.53) | CSNK2A1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3640612 | 0.84 | AMY1A (0.54) | CSNK2A1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1041244 | 0.84 | CYP1A1 (0.53) | CSNK2A1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3640999 | 0.84 | CYP1B1 (0.53) | CSNK2A1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3635139 | 0.83 | ALOX5 (0.69) | CYP3A4KMT2AMEN1MAPTTDP1 | |
| SCHEMBL3634967 | 0.81 | ALOX5 (0.55) | CSNK2A1KMT2AMEN1NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155740-A1 | HETARYLANILINES AS MODULATORS FOR AMYLOID BETA | F. Hoffmann-Roche AG (CH) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008138753-A1 | HETARYLANILINES AS MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2008-11-20 | — | — | WO | disclosed |